【摘要】：目的探討苯暴露對工人血常規(guī)指標(biāo)的影響,并以3.25 mg/m~3(1 ppm)、0.325 mg/m~3(0.1 ppm)為界值探討不同范圍的苯暴露對各血常規(guī)指標(biāo)的影響。方法在PubMed、Scopus、SinoMed、中國知網(wǎng)、萬方、維普等數(shù)據(jù)庫檢索2016年5月1日之前發(fā)表的關(guān)于苯作業(yè)人群苯暴露及其血常規(guī)指標(biāo)計(jì)數(shù)情況的文獻(xiàn),采用隨機(jī)和固定效應(yīng)模型,計(jì)算合并標(biāo)準(zhǔn)均數(shù)差(SMD)及其95%可信區(qū)間(95%CI),同時(shí)根據(jù)苯暴露濃度對數(shù)據(jù)進(jìn)行亞組分析。結(jié)果本次研究共納入30篇符合標(biāo)準(zhǔn)的文獻(xiàn)。meta分析結(jié)果表明,苯暴露工人白細(xì)胞、紅細(xì)胞、血小板、中性粒細(xì)胞、淋巴細(xì)胞、血紅蛋白等血常規(guī)指標(biāo)計(jì)數(shù)與對照組相比明顯降低。進(jìn)一步的亞組分析發(fā)現(xiàn),當(dāng)苯暴露濃度高于3.25 mg/m~3時(shí),白細(xì)胞、紅細(xì)胞、血小板、中性粒細(xì)胞、淋巴細(xì)胞、血紅蛋白等6項(xiàng)血常規(guī)指標(biāo)計(jì)數(shù)明顯下降;當(dāng)苯暴露濃度在0.325~3.25 mg/m~3時(shí),白細(xì)胞、血小板、血紅蛋白等3項(xiàng)血常規(guī)指標(biāo)計(jì)數(shù)明顯下降;當(dāng)苯暴露濃度低于0.325 mg/m~3時(shí),僅紅細(xì)胞計(jì)數(shù)明顯下降,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論職業(yè)苯暴露與工人多個(gè)血常規(guī)指標(biāo)的異常有關(guān),即使在低于3.25 mg/m~3的暴露濃度下,苯暴露也具有血液毒性;白細(xì)胞、血小板、血紅蛋白等指標(biāo)對低濃度苯暴露的毒性效應(yīng)更敏感。
[Abstract]:Objective to investigate the effect of benzene exposure on blood routine indexes of workers, and to explore the effect of benzene exposure in different ranges on blood routine indexes with 3.25 mg/m~3 (1 ppm) 0.325 mg/m~3 (0. 1 ppm) as the boundary value. Methods the data of benzene exposure and its blood routine index count in benzene exposed population were searched in PubMed,Scopus,SinoMed, China Zhiwang, Wanfang and Weip databases before May 1, 2016. Random and fixed effect models were used. The combined standard mean difference (SMD) and its 95% confidence interval (95%CI) were calculated. Results A total of 30 documents were included in this study. The results of meta analysis showed that the counts of leukocytes, erythrocytes, platelets, neutrophils, lymphocytes and hemoglobin in workers exposed to benzene were significantly lower than those in the control group. Further subgroup analysis showed that when benzene exposure concentration was higher than 3.25 mg/m~, the counts of leukocytes, red blood cells, platelets, neutrophils, lymphocytes, hemoglobin and so on were significantly decreased, and when benzene exposure concentration was 0.325 鹵3.25 mg/m~, WBC, platelet, hemoglobin and other blood routine indexes were significantly decreased; when benzene exposure concentration was lower than 0.325 mg/m~ 3, only red blood cell count decreased significantly (P0.05). Conclusion the occupational benzene exposure is related to the abnormal blood routine indexes of workers. Even when the exposure concentration is lower than 3.25 mg/m~3, benzene exposure also has hematotoxicity, white blood cells, platelets, platelet, leukocyte, platelets, leucocytes, platelets, leukocytes, and platelets. Hemoglobin and other indicators are more sensitive to the toxic effects of low concentration benzene exposure.
【作者單位】： 中山大學(xué)公共衛(wèi)生學(xué)院預(yù)防醫(yī)學(xué)系廣州市環(huán)境污染與健康風(fēng)險(xiǎn)評價(jià)重點(diǎn)實(shí)驗(yàn)室;
【基金】：國家自然科學(xué)基金重點(diǎn)項(xiàng)目(81430079);國家自然科學(xué)基金面上項(xiàng)目(81372962)
【分類號】：R135

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