本文關(guān)鍵詞： 睪丸 煙草 煙霧 毒物 雄性大鼠 一氧化氮　出處：《重慶醫(yī)學》2017年14期 　論文類型：期刊論文

【摘要】：目的探討香煙煙霧染毒對大鼠睪丸組織結(jié)構(gòu)及睪丸組織一氧化氮(NO)水平的影響。方法清潔級成年雄性SD大鼠160只,分為對照組和低、中、高劑量染毒組,各組大鼠分別染毒2、4、6、8、12周,每組10只。染毒組采用呼吸道靜式染毒,每天1次,每次0.5h。觀察大鼠睪丸組織結(jié)構(gòu),檢測各組大鼠體質(zhì)量及睪丸組織NO水平。結(jié)果染毒4、6、8、12周時,中、高劑量染毒組大鼠體質(zhì)量與對照組和低劑量組相比均明顯降低(P0.05),染毒8、12周時,高劑量染毒組大鼠體質(zhì)量與中劑量組相比明顯降低(P0.05),并且隨著染毒劑量的增加,降低更加明顯。染毒2、4、6、8周時,高劑量組大鼠睪丸組織NO水平與對照組和低、中劑量組相比均明顯升高(P0.05);染毒8周時,中劑量組大鼠睪丸組織NO水平與對照組相比明顯升高(P0.05);染毒12周時,低、中、高劑量組大鼠睪丸組織NO水平與對照組相比均明顯升高(P0.05),中、高劑量組大鼠睪丸組織NO水平與低劑量組相比明顯升高(P0.05)。結(jié)論香煙煙霧染毒可致雄性大鼠睪丸組織NO水平升高,導致雄性大鼠睪丸組織損傷。
[Abstract]:Objective to investigate the cigarette smoke exposure on testicular tissue structure and testicular tissue of rats (NO) were investigated. Methods clean adult male SD 160 rats were divided into control group and low, high dose group, the rats were exposed to 2,4,6,8,12 weeks, 10 rats in each group. The treated group with static respiratory tract inhalation, 1 times a day, to observe the testicular tissue structure of rat 0.5H. every time, the level of NO body weight and testicular tissue of rats was detected. Results after 4,6,8,12 weeks of age, body mass, high dose treated rats compared with control group and low dose group were significantly decreased (P0.05), after 8,12 weeks high dose group, rats body weight decreased significantly compared with the medium dose group (P0.05), and as the dose increased, decreased obviously. After 2,4,6,8 weeks, the high dose group of rat testis tissue NO levels compared with the control group and low dose group were compared, in Ming Dynasty Xian Shenggao (P0.05); after 8 weeks, the middle dose group of rat testicular tissue NO levels increased significantly compared with the control group (P0.05); after 12 weeks, low and high dose group rat testicular tissue NO levels were significantly increased compared with the control group (P0.05), NO in the testis tissue rats in high dose group compared with the low dose group increased significantly (P0.05). The level of NO increased in testis of male rats exposed to cigarette smoke can lead to the conclusion, testicular tissue injury in male rats.

【作者單位】： 新疆醫(yī)科大學公共衛(wèi)生學院毒理學教研室;新疆維吾爾自治區(qū)疾病預(yù)防控制中心;
【基金】：國家自然科學基金資助項目(81260433) 新疆維吾爾自治區(qū)自然科學基金項目(2014211C015)
【分類號】：R114
【正文快照】： 男性生殖健康問題是影響家庭和諧和社會穩(wěn)定的重要醫(yī)學問題。目前,男性精液質(zhì)量下降造成的不育問題已經(jīng)引起了全世界的關(guān)注。香煙煙霧中含有多種致癌物質(zhì)和細胞誘變劑,可能對男性生育產(chǎn)生不利影響[1]。WHO指出,煙草危害是現(xiàn)今全球最嚴峻的公共衛(wèi)生問題之一[2]。據(jù)統(tǒng)計,全球15

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