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  本文關(guān)鍵詞： PET-CT ~(18)F-FDG 輻射防護 有效劑量 輻射劑量　出處：《鄭州大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：PET-CT實現(xiàn)了功能成像和解剖顯像同機融合,可精確提供靶器官的功能和解剖雙重信息,是目前最為先進的影像檢查技術(shù)之一,尤其在腫瘤分期、療效評估、良惡性鑒別等方面發(fā)揮重要作用。在PET-CT檢查流程中,受檢者因注射放射性示蹤劑會對其本人及其接觸者產(chǎn)生輻射危害。~(18)F-FDG是目前臨床應(yīng)用最廣的正電子示蹤劑,在PET-CT顯像中食管癌患者占很大比例,目前對該類患者及相關(guān)人群所受的輻射劑量研究尚未見諸報道。本研究追蹤食管癌患者~(18)F-FDG PET-CT顯像過程,對食管癌患者及相關(guān)人員受到的輻射劑量進行估算與評價,以期為臨床輻射防護提供參考依據(jù)。本研究收集2015年3月~2016年5月在河南省腫瘤醫(yī)院PET-CT中心行~(18)F-FDG PET-CT顯像的食管癌患者100例,男56例,女44例,年齡23~81歲,平均(54.7±14.3)歲。入組標(biāo)準(zhǔn)為經(jīng)病理確診且PET-CT顯像無轉(zhuǎn)移患者,排除標(biāo)準(zhǔn)為無病理診斷或PET-CT顯像有轉(zhuǎn)移患者。100例PET-CT全身顯像食管癌患者,利用劑量長度乘積值估算受檢者CT掃描所致輻射有效劑量(ED),依據(jù)ICRP出版物推薦方法估算受檢者~(18)F-FDG所致輻射ED;檢測相關(guān)人員在不同防護策略下初始劑量當(dāng)量率(IDR),估算相關(guān)人群所受輻射劑量(RD)。本研究結(jié)果表明食管癌患者ED為(15.24~26.94)mSv,平均值(20.87±2.06)mSv。在不同防護策略下,全程陪同家屬、同病房病友及同病房其他家屬每接觸1例顯像患者RD分別為(26.96~~(18)3.30)μSv、(11.27~45.39)μSv、(5.66~17.84)μSv�；诂F(xiàn)有防護策略按每年4500例受檢患者,分裝護士手部與體部年受照劑量分別為8.96mSv和0.81mSv;注射護士手部與體部年受照劑量分別為13.46mSv和0.63m Sv;技師體部年受照劑量0.9mSv。本論文對食管癌患者行PET-CT檢查流程中相關(guān)人員在不同防護策略下受照劑量進行了定量分析與研究,以期為臨床實踐中相關(guān)人員的輻射劑量計算與防護優(yōu)化提供參考依據(jù)。
[Abstract]:PET-CT is one of the most advanced imaging techniques, especially in tumor staging, because it can accurately provide the dual information of function and anatomy of target organs by using the same computer fusion of functional imaging and anatomical imaging. It plays an important role in the evaluation of curative effect and differential diagnosis of benign and malignant. It plays an important role in the process of PET-CT examination. At present, F-FDG is the most widely used positron tracer in clinical practice, because radioactive tracer can cause radiation hazard to themselves and their contacts. Esophageal cancer patients accounted for a large proportion in PET-CT imaging. At present, there is no report on the radiation dose of this kind of patients and related population. This study tracks the process of 18F-FDG PET-CT imaging in patients with esophageal cancer. The dose of radiation to esophageal cancer patients and related personnel was estimated and evaluated. In order to provide reference for clinical radiation protection, this study collected and collected from March 2015 to May 2016 at the PET-CT Center of Henan Cancer Hospital. F-FDG PET-CT imaging was performed in 100 patients with esophageal carcinoma. There were 56 males and 44 females, aged 2381 years (mean 54.7 鹵14.3) years. The criteria of admission were confirmed by pathology and no metastasis by PET-CT imaging. The exclusion criteria were: no pathological diagnosis or PET-CT imaging with metastasis. 100 patients with esophageal carcinoma by PET-CT systemic imaging. The dose length product value was used to estimate the effective dose of radiation induced by CT scan, and the recommended method of ICRP publication was used to estimate the radiation EDT caused by 18F-FDG. The initial dose equivalent rate (IDR) was measured under different protective strategies. The results of this study showed that Ed was 15.24 ~ 26.94 mSv in patients with esophageal cancer. The average value was 20.87 鹵2.06mSv.Under different protective strategies, the family members were accompanied in the whole course. The Rd of one patient in the same ward and other family members in the same ward were 26.96 ~ 183.30) 渭 Svn and 11.27 ~ 45.39 渭 Sv respectively. According to the existing protective strategies, the annual radiation doses of hand and body were 8.96mSv and 0.81mSv, respectively. The annual radiation doses of hand and body were 13.46mSv and 0.63mSv, respectively. The annual radiation dose of technicians was 0.9mSv.In this paper, quantitative analysis and study of radiation dose in the process of PET-CT examination for patients with esophageal cancer under different protective strategies were carried out. In order to provide reference basis for radiation dose calculation and protection optimization in clinical practice.
【學(xué)位授予單位】：鄭州大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R735.1;R144

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本文編號：1449297