發(fā)布時間：2019-05-10 08:42

【摘要】：目的:系統(tǒng)評價大劑量甲基強的松龍沖擊療法與安慰劑治療急性視神經(jīng)炎的臨床療效和安全性。方法:檢索Medline、OVID和中文科技期刊全文數(shù)據(jù)庫、維普中文科技期刊數(shù)據(jù)庫,檢索時間截至2009年5月。按照文內(nèi)所述納入標(biāo)準(zhǔn)收集大劑量靜脈應(yīng)用激素沖擊治療急性視神經(jīng)炎的相關(guān)研究文獻(xiàn),采用Meta分析對檢索文獻(xiàn)進(jìn)行綜合定量評價。結(jié)果:IVMP與安慰劑比較共納入3個研究433例患者,IVMP在早期顯示出相對優(yōu)于安慰劑組的有效率,但在六個月后,兩組有效率的差異無統(tǒng)計學(xué)意義。結(jié)論:早期靜脈注射大劑量甲基強的松龍可加快急性視神經(jīng)炎的康復(fù),六個月后與安慰劑組無明顯差別。在降低急性視神經(jīng)炎的復(fù)發(fā)率、甲基強的松龍的最佳用藥劑量及療程仍需開展更多設(shè)計良好、方法學(xué)質(zhì)量更高的隨機對照試驗來證實。
[Abstract]:Objective: to evaluate the clinical efficacy and safety of high dose methylprednisolone pulse therapy and placebo in the treatment of acute optic neuropathy. Methods: Medline,OVID and Chinese sci-tech periodical full-text database and VIP Chinese sci-tech periodical database were searched up to May 2009. According to the inclusion criteria described in this paper, the related research literature of high dose intravenous hormone shock therapy for acute optic neuropathy was collected, and the retrieval literature was evaluated comprehensively and quantitatively by Meta analysis. Results: a total of 433 patients with IVMP and placebo were enrolled in the study. IVMP showed a relatively superior effective rate to the placebo group at an early stage, but after six months, there was no significant difference in the effective rate between the two groups. Conclusion: early intravenous injection of high dose methylprednisolone can accelerate the recovery of acute optic neuropathy, and there is no significant difference between the placebo group and the placebo group after six months. In order to reduce the recurrence rate of acute optic neuropathy, the best dose and course of treatment of methylprednisolone still need to be confirmed by more randomized controlled trials with good design and higher methodological quality.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2010
【分類號】：R774.6

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 陳貽言;甲潑尼松龍聯(lián)合施普善治療急性視神經(jīng)炎療效觀察[J];國際眼科雜志;2004年03期

2 藍(lán)育青;張馳;夏朝霞;彭蔚;肖劍暉;;急性視神經(jīng)炎臨床特征和療效分析[J];國際眼科雜志;2008年09期

3 陳衛(wèi)東,楊任民;大劑量甲基強的松龍沖擊療法在神經(jīng)免疫性疾病的應(yīng)用[J];臨床神經(jīng)病學(xué)雜志;1992年02期

4 趙長龍,方嚴(yán);視神經(jīng)損傷藥物治療的新進(jìn)展[J];臨床眼科雜志;2000年05期

5 張彩;王大博;白海青;商衛(wèi)衛(wèi);房嬌;李廷;;糖皮質(zhì)激素治療視神經(jīng)炎療效評價及影響療效因素分析[J];眼科新進(jìn)展;2008年12期

6 王書華,宋維賢,王懷洲;外傷性視神經(jīng)病變的甲基強的松龍沖擊療法[J];眼外傷職業(yè)眼病雜志.附眼科手術(shù);2001年03期

7 曾艷;;急性球后視神經(jīng)炎的治療體會[J];中國現(xiàn)代醫(yī)藥雜志;2007年05期

8 嚴(yán)密;關(guān)于視神經(jīng)炎治療的新概念[J];中華眼底病雜志;2000年02期

9 張曉君;王薇;王虔;魏文斌;魏永祥;;視神經(jīng)炎病因?qū)W臨床分析[J];中華眼底病雜志;2006年06期

10 徐昭旭,高國勛;大劑量甲基強的松龍沖擊療法治療急性視神經(jīng)炎臨床療效觀察[J];中華眼底病雜志;1996年03期

，

本文編號：2473509