發(fā)布時(shí)間：2019-03-07 23:08

【摘要】：目的：研究晚期鼻咽癌組織中ki一67的表達(dá)及其與化療療效的關(guān)系,探討Ki-67可否作為化療的敏感預(yù)測(cè)因子及預(yù)測(cè)生存的獨(dú)立預(yù)后因素。 方法：通過(guò)對(duì)64例晚期鼻咽癌患者的腫瘤組織中Ki-67的表達(dá)與患者的年齡、TNM分期、化療療效關(guān)系的分析,探討晚期鼻咽癌患者腫瘤組織中Ki-67的表達(dá)對(duì)化療療效和預(yù)后預(yù)測(cè)等方面的意義。 結(jié)果：在本研究對(duì)象中Ki一67陽(yáng)性率為70.3%。Ki-67表達(dá)與患者年齡、TNM分期不相關(guān)(P0.05)。Ki-67低表達(dá)組化療有效率(RR)為88.6%；Ki-67高表達(dá)組化療有效率(RR)為75.9%,兩組間比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。在使用不同化療方案化療時(shí),無(wú)論是在PF化療方案組或非PF化療方案組均未發(fā)現(xiàn)ki-67與化療療效間有明顯的相關(guān)性(P0.05)。遠(yuǎn)期生存方面,Ki-67低表達(dá)組與高表達(dá)組比較未顯示出明顯的生存優(yōu)勢(shì),其1年、3年及5年生存率與高表達(dá)組比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。 結(jié)論：在晚期鼻咽癌組織中,Ki-67表達(dá)與鼻咽癌患者年齡、TNM分期、及化療療效不相關(guān)性,與預(yù)后亦無(wú)明顯相關(guān)性。因此,Ki-67不能作為晚期鼻咽癌化療敏感性的預(yù)測(cè)指標(biāo),也不能作為判斷晚期鼻咽癌預(yù)后的預(yù)測(cè)指標(biāo)。
[Abstract]:Aim: to study the expression of Ki-67 in advanced nasopharyngeal carcinoma (NPC) and the relationship between Ki-67 expression and the efficacy of chemotherapy. To explore whether Ki-67 can be used as a sensitive predictor of chemotherapy and an independent prognostic factor in predicting survival. Methods: the relationship between the expression of Ki-67 and the age, TNM stage and curative effect of chemotherapy in 64 cases of advanced nasopharyngeal carcinoma (NPC) was analyzed. To investigate the significance of the expression of Ki-67 in tumor tissue of advanced nasopharyngeal carcinoma (NPC) in predicting the curative effect and prognosis of chemotherapy. Results: the positive rate of Ki-67 was not correlated with the age and TNM stage of the patients (P0.05). The effective rate of chemotherapy was 88.6% in the low expression group of Ki-67. The expression of 70.3%.Ki-67 was not correlated with the age and TNM stage of the patients (P0.05). The effective rate of chemotherapy in Ki-67 high expression group was 75.9%, and there was no significant difference between the two groups (P0.05). There was no significant correlation between ki-67 and the efficacy of chemotherapy in PF chemotherapy group or non-PF chemotherapy group when different chemotherapy regimens were used (P0.05). In terms of long-term survival, there was no significant difference in the 1 -, 3-and 5-year survival rates between the low expression group and the high expression group (P0.05). There was no significant difference between the Ki-67 low expression group and the high expression group (P0.05). Conclusion: in advanced nasopharyngeal carcinoma, the expression of Ki-67 is not correlated with age, TNM stage, chemotherapy effect and prognosis. Therefore, Ki-67 can not be used as a predictor of chemosensitivity of advanced nasopharyngeal carcinoma, nor can it be used as a predictor of prognosis of advanced nasopharyngeal carcinoma.
【學(xué)位授予單位】：廣西醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2011
【分類號(hào)】：R739.63

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