阻塞性睡眠呼吸暫停低通氣綜合征與動(dòng)脈粥樣硬化相關(guān)性的臨床研究
發(fā)布時(shí)間：2018-12-17 20:51
【摘要】：第一部分OSAHS患者血尿酸水平與頸動(dòng)脈粥樣硬化的關(guān)系 目的探討阻塞性睡眠呼吸暫停低通氣綜合征(OSAHS)患者病情與血漿尿酸(UA)水平及頸動(dòng)脈粥樣硬化的關(guān)系。方法選取經(jīng)多導(dǎo)睡眠監(jiān)測(cè)儀(PSG)診斷的OSAHS患者64例,根據(jù)呼吸暫停低通氣指數(shù)(AHI)分為輕度亞組20例,中度亞組22例,重度亞組22例。應(yīng)用彩色多普勒超聲檢測(cè)頸動(dòng)脈內(nèi)-中膜厚度(IMT),測(cè)定血UA的水平,并與20名正常對(duì)照組比較。結(jié)果輕度、中度、重度OSAHS亞組患者的血UA水平均顯著高于正常對(duì)照組,且OSAHS各亞組間差異有統(tǒng)計(jì)學(xué)意義(均P0.01);OSAHS重度亞組頸動(dòng)脈IMT較正常對(duì)照組和OSAHS輕度亞組明顯增厚(均P0.01);血UA水平與頸動(dòng)脈IMT、AHI呈正相關(guān)(r=0.746, r=0.798),與夜間最低血氧飽和度(SpO2)負(fù)相關(guān)(r =-0.754)(均P0.01)。結(jié)論OSAHS患者頸動(dòng)脈IMT增厚,血UA水平升高,并可反映OSAHS嚴(yán)重程度。 第二部分OSAHS患者頸動(dòng)脈及下肢動(dòng)脈硬化斑塊的臨床研究 目的探討中青年OSAHS患者與頸動(dòng)脈和下肢動(dòng)脈粥樣硬化斑塊之間的關(guān)系。方法應(yīng)用PSG診斷的110例OSAHS患者分成輕度組(36例)、中度組(38例)、重度組(36例),另設(shè)36名健康體檢者作為對(duì)照組,所有入選者行頸動(dòng)脈和下肢動(dòng)脈彩色多普勒超聲檢測(cè)。結(jié)果OSAHS患者頸動(dòng)脈和(或)下肢動(dòng)脈粥樣硬化斑塊檢出率明顯高于對(duì)照組(P0.05),且隨著程度加重斑塊的發(fā)生率有增加的趨勢(shì)。結(jié)論OSAHS是動(dòng)脈粥樣硬化的獨(dú)立影響因素。
[Abstract]:Part I the relationship between serum uric acid level and carotid atherosclerosis in patients with OSAHS objective to investigate the relationship between serum uric acid (UA) level and carotid atherosclerosis in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods Sixty-four patients with OSAHS diagnosed by polysomnography (PSG) were divided into mild subgroup (n = 20), moderate subgroup (n = 22) and severe subgroup (n = 22) according to apnea hypopnea index (AHI). The level of blood UA was measured by color Doppler ultrasound (CDFI) in carotid intima-media thickness (IMT), and compared with that in 20 normal controls. Results the serum UA levels in mild, moderate and severe OSAHS subgroups were significantly higher than those in normal controls, and there were significant differences among OSAHS subgroups (P0.01). The carotid IMT in the severe subgroup of OSAHS was significantly thicker than that in the normal control group and the mild subgroup of OSAHS (P0.01). The serum UA level was positively correlated with carotid IMT,AHI (r = 0.746, r = 0.798), and negatively correlated with nocturnal minimum oxygen saturation (SpO2) (r =-0.754). Conclusion carotid IMT is thickened and serum UA level is increased in OSAHS patients, which can reflect the severity of OSAHS. The second part: clinical study of carotid and lower extremity arteriosclerotic plaques in patients with OSAHS objective to investigate the relationship between carotid artery and lower extremity atherosclerotic plaques in young and middle-aged patients with OSAHS. Methods 110 patients with OSAHS diagnosed by PSG were divided into three groups: mild group (36 cases), moderate group (38 cases), severe group (36 cases). The carotid and lower extremity arteries were detected by color Doppler ultrasound. Results the detection rate of carotid and / or lower extremity atherosclerotic plaques in OSAHS patients was significantly higher than that in the control group (P0.05), and the incidence of plaque increased with the severity of Atherosclerotic plaque. Conclusion OSAHS is an independent factor of atherosclerosis.
【學(xué)位授予單位】：華中科技大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2010
【分類號(hào)】：R766
本文編號(hào)：2384781
[Abstract]:Part I the relationship between serum uric acid level and carotid atherosclerosis in patients with OSAHS objective to investigate the relationship between serum uric acid (UA) level and carotid atherosclerosis in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods Sixty-four patients with OSAHS diagnosed by polysomnography (PSG) were divided into mild subgroup (n = 20), moderate subgroup (n = 22) and severe subgroup (n = 22) according to apnea hypopnea index (AHI). The level of blood UA was measured by color Doppler ultrasound (CDFI) in carotid intima-media thickness (IMT), and compared with that in 20 normal controls. Results the serum UA levels in mild, moderate and severe OSAHS subgroups were significantly higher than those in normal controls, and there were significant differences among OSAHS subgroups (P0.01). The carotid IMT in the severe subgroup of OSAHS was significantly thicker than that in the normal control group and the mild subgroup of OSAHS (P0.01). The serum UA level was positively correlated with carotid IMT,AHI (r = 0.746, r = 0.798), and negatively correlated with nocturnal minimum oxygen saturation (SpO2) (r =-0.754). Conclusion carotid IMT is thickened and serum UA level is increased in OSAHS patients, which can reflect the severity of OSAHS. The second part: clinical study of carotid and lower extremity arteriosclerotic plaques in patients with OSAHS objective to investigate the relationship between carotid artery and lower extremity atherosclerotic plaques in young and middle-aged patients with OSAHS. Methods 110 patients with OSAHS diagnosed by PSG were divided into three groups: mild group (36 cases), moderate group (38 cases), severe group (36 cases). The carotid and lower extremity arteries were detected by color Doppler ultrasound. Results the detection rate of carotid and / or lower extremity atherosclerotic plaques in OSAHS patients was significantly higher than that in the control group (P0.05), and the incidence of plaque increased with the severity of Atherosclerotic plaque. Conclusion OSAHS is an independent factor of atherosclerosis.
【學(xué)位授予單位】：華中科技大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2010
【分類號(hào)】：R766
【參考文獻(xiàn)】
相關(guān)期刊論文 前2條
1 張紅;張錦;;OSAHS及高血壓患者血清尿酸水平的臨床研究[J];寧夏醫(yī)學(xué)雜志;2007年07期
2 中華醫(yī)學(xué)會(huì)呼吸病學(xué)分會(huì)睡眠呼吸疾病學(xué)組;阻塞性睡眠呼吸暫停低通氣綜合征診治指南(草案)[J];中華結(jié)核和呼吸雜志;2002年04期
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