【摘要】： 目的 鼻內(nèi)翻性乳頭狀瘤(NIP)是一種發(fā)生于鼻腔鼻竇粘膜上皮組織的良性腫瘤,占鼻部腫瘤的0.5%-4%,因復發(fā)率高和易惡變等特征,目前成為研究熱點。通過徹底手術可解決復發(fā)的問題,但惡變的機制尚未明確,目前仍缺乏判斷NIP惡變傾向的可靠依據(jù)。通過對NIP相關因子的深入研究,找到預測NIP惡變的可靠證據(jù),指導臨床對高�；颊哌M行重點監(jiān)測,對提高NIP患者的無瘤生存率是很有必要的。TGF信號轉(zhuǎn)導通路廣泛參與細胞的分化、增殖及凋亡等,在頭頸腫瘤的發(fā)生發(fā)展過程中起著重要的作用。TGF-β1、TβR-Ⅱ是TGF信號轉(zhuǎn)導通路的樞紐因子,若其中任一因子失活均可導致TGF信號傳導通路中斷,生長失控,誘導瘤體形成。本研究旨在探討TGF-β1及Ⅱ型受體(TβR-Ⅱ)在NIP中的表達及與NIP惡變的關系,為臨床提供堅實的理論依據(jù)。 方法 回顧性分析72例經(jīng)病理證實為NIP的患者資料,將其按病理分為NIP良性病變組、NIP生長活躍伴不典型增生組、NIP惡變組,用應用免疫組化檢測TGF-β1和TβR-Ⅱ在各組中的表達情況,另以10例同期鼻息肉手術標本做為對照組。 結果 72例患者惡變率是16.67%(12／72),同時惡變率4.17%(3／72),異時惡變率12.50%(9／72)。TGF-β1在NIP惡變組織、NIP良性病變組織、鼻息肉組織中的陽性表達率分別為91.67%、34.09%和30%,NIP惡變組織中的TGF-β1陽性表達高于NIP良性病變組織和鼻息肉組(P0.05)；而TβR-Ⅱ在NIP惡變組織中表達缺失,在NIP良性病變組(40.91%)和鼻息肉組(40%)中表達增高,經(jīng)比較差異有統(tǒng)計學意義(P0.05)；TGF-β1在NIP伴不典型增生組陽性表達率(68.75%)與NIP惡變組比較無明顯差異(P0.05)。匯總?cè)MNIP, TGF-β1和TβR-Ⅱ表達呈負相關。 結論 TGF-β1、TβR-Ⅱ表達異常與NIP惡變密切相關,但與NIP的發(fā)生可能無關；對伴不典型增生NIP進行TGF-β1和TβR-Ⅱ蛋白的聯(lián)合檢測預測NIP惡變提供參考。
[Abstract]:Objective nasal inverted papilloma (NIP) is a kind of benign tumor occurring in nasal cavity and sinusoid mucosa, which accounts for 0.5-4% of nasal tumor. The recurrence problem can be solved by thorough operation, but the mechanism of malignant change is not clear, and there is still no reliable basis for judging the tendency of NIP malignancy. Through the in-depth study of the related factors of NIP, the reliable evidence of predicting the malignant change of NIP was found, and the clinical monitoring of high-risk patients was guided. It is necessary to improve the tumor-free survival rate of NIP patients. TGF signal transduction pathway is widely involved in cell differentiation, proliferation and apoptosis, and plays an important role in the occurrence and development of head and neck tumors. T 尾 R- 鈪，

本文編號：2369562