發(fā)布時間：2018-11-03 18:18

【摘要】：目的探討腎陽虛體質(zhì)對負透鏡誘導(dǎo)豚鼠的屈光度、眼軸長度及后極部鞏膜厚度的影響。方法選取24只3周齡雄性健康三色短毛豚鼠,隨機分為正常對照組、透鏡誘導(dǎo)組和腎陽虛+透鏡誘導(dǎo)組,每組各8只。腎陽虛+透鏡誘導(dǎo)組每日腹腔注射氫化可的松注射液,劑量10 mg·kg-1,正常對照組和透鏡誘導(dǎo)組則注射等量生理鹽水,每日1次,連續(xù)2周。第3周起,透鏡誘導(dǎo)組、腎陽虛+透鏡誘導(dǎo)組右眼均戴-10.00 D透鏡,左眼作為自身對照眼,正常對照組則不作任何處理,透鏡誘導(dǎo)2周后各組進行屈光度、眼軸長度及后極部鞏膜厚度的測量。結(jié)果透鏡誘導(dǎo)組自身對照眼屈光度、眼軸長度和后極部鞏膜厚度分別為(1.52±0.45)D、(8.52±0.04)mm、(291.25±18.08)μm,與之相比透鏡誘導(dǎo)組造模眼近視屈光度增加為(-2.16±0.09)D,眼軸延長為(8.61±0.03)mm,后極部鞏膜厚度降低為(233.75±23.26)μm(均為P0.01);腎陽虛+透鏡誘導(dǎo)組自身對照眼屈光度、眼軸長度和后極部鞏膜厚度分別為(1.56±0.18)D、(8.53±0.09)mm、(296.25±22.64)μm,與之相比腎陽虛+透鏡誘導(dǎo)組造模眼近視屈光度增加為(-2.73±0.55)D,眼軸延長為(8.70±0.10)mm,后極部鞏膜厚度降低為(180.00±16.04)μm(均為P0.01);與透鏡誘導(dǎo)組造模眼相比,腎陽虛+透鏡誘導(dǎo)組造模眼近視屈光度增加更多,眼軸延長更顯著,后極部鞏膜厚度降低更明顯(均為P0.05)。結(jié)論在負透鏡誘導(dǎo)下,腎陽虛豚鼠較正常豚鼠眼軸延長和近視度增加更加顯著,腎陽虛體質(zhì)與近視的發(fā)生發(fā)展可能有密切聯(lián)系。
[Abstract]:Objective to investigate the effects of kidney-yang deficiency constitution on diopter, axial length and sclera thickness of posterior pole in guinea pigs induced by negative lens. Methods 24 healthy 3-week-old male short-haired guinea pigs were randomly divided into three groups: normal control group, lens induced group and kidney-yang deficiency lens group, with 8 guinea pigs in each group. Hydrocortisone was injected intraperitoneally in the kidney-yang deficiency lens induction group, and the normal control group and lens induced group were injected with the same amount of normal saline once a day for 2 weeks at a dose of 10 mg kg-1,. From the third week, the right eye of the lens induction group and the kidney-yang deficiency lens group were all wearing -10.00D lens, the left eye was used as self-control eye, and the normal control group was not treated with any treatment. After 2 weeks of lens induction, the diopter was given in each group. Measurement of axial length and posterior sclera thickness. Results the diopter, axial length and scleral thickness of posterior pole were (1.52 鹵0.45) D, () 8.52 鹵0.04) mm, (291.25 鹵18.08) 渭 m, respectively. Compared with the model group, the myopia diopter increased to (-2.16 鹵0.09) D and the axial length was (8.61 鹵0.03) mm,. The thickness of sclera decreased to (233.75 鹵23.26) 渭 m (all P0.01). The diopter, axial length and sclera thickness of posterior pole were (1.56 鹵0.18) D, () 8.53 鹵0.09) mm, (296.25 鹵22.64) 渭 m, respectively. Compared with the model group, the myopia diopter was increased to (-2.73 鹵0.55) D, and the axial length was (8.70 鹵0.10) mm,. The sclera thickness decreased to (180.00 鹵16.04) 渭 m (all P0.01). Compared with the model eyes induced by lens, the myopia diopter increased more, the eye axis lengthened more significantly, and the scleral thickness of the posterior pole decreased more significantly in the model eyes induced by kidney-yang deficiency lens group (P0.05). Conclusion induced by negative lens, the axial lengthening and myopia of kidney yang deficiency guinea pigs are more significant than that of normal guinea pigs, and the constitution of kidney yang deficiency may be closely related to the occurrence and development of myopia.
【作者單位】： 山東中醫(yī)藥大學(xué);山東中醫(yī)藥大學(xué)附屬眼科醫(yī)院;山東中醫(yī)藥大學(xué)眼科研究所;
【基金】：國家自然科學(xué)基金資助(編號:81303081、81173440) 山東省科技發(fā)展計劃(編號:2011GGB14097、2013GSF11857) 山東省醫(yī)藥衛(wèi)生科技發(fā)展計劃(編號:2011HD014) 濟南市高校自主創(chuàng)新計劃(編號:201102061)~~
【分類號】：R778.11

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