本文選題：快速老化小鼠 + 耳蝸��； 參考：《聽力學(xué)及言語疾病雜志》2014年04期

【摘要】：目的探討快速老化小鼠的聽功能及耳蝸組織神經(jīng)生長因子受體p75(nerve growth factor receptor p75,NGFR p75)表達的增齡性變化特點。方法對3、5、7月齡的快速老化小鼠亞系8(SAMP8小鼠)行8kHz短純音聽性腦干反應(yīng)(ABR)檢測,并用免疫組化染色方法檢測耳蝸組織NGFR p75的表達,觀察隨月齡的增長其ABR反應(yīng)閾和NGFR p75的表達變化。結(jié)果 SAMP8小鼠ABR反應(yīng)閾值隨著月齡增加而顯著增高(P0.05);NGFR p75在不同月齡SAMP8小鼠耳蝸螺旋神經(jīng)節(jié)和毛細胞中均有表達,其光密度值隨著月齡增加而顯著增高(P0.05)。結(jié)論快速老化小鼠NGFR p75的表達水平隨著聽覺功能的年齡相關(guān)性減退而增高,說明NGFR p75可能與耳蝸功能增齡性退化有關(guān)。
[Abstract]:Objective to investigate the auditory function and age-related changes of nerve growth factor receptor (p75(nerve growth factor receptor p75) expression in cochlear tissue of aging mice. Methods the 8kHz short tone auditory brainstem response (ABR) and the expression of NGFR p75 in cochlea were detected by immunohistochemical staining. The ABR response threshold and the expression of NGFR p75 were observed with the increase of age. Results the ABR response threshold of SAMP8 mice was significantly increased with the increase of age, and the expression of p75 in cochlear spiral ganglion and hair cells was significantly increased with the increase of age. The optical density of SAMP8 mice increased significantly with the increase of month age (P 0.05). Conclusion the expression level of NGFR p75 in rapidly aging mice increases with the decrease of age related to auditory function, suggesting that NGFR p75 may be related to cochlear aging degeneration.
【作者單位】： 桂林醫(yī)學(xué)院附屬醫(yī)院耳鼻咽喉-頭頸外科;桂林醫(yī)學(xué)院耳鼻咽喉科學(xué)研究所;
【基金】：國家自然科學(xué)基金(81060083) 廣西科學(xué)研究與技術(shù)開發(fā)計劃項目(桂科攻10124001B-56)聯(lián)合資助
【分類號】：R764

【相似文獻】

相關(guān)碩士學(xué)位論文 前1條

1 黃鑫;快速老化癡呆小鼠智力、聽功能、以及耳蝸螺旋神經(jīng)節(jié)細胞MeCP2的增齡性變化[D];桂林醫(yī)學(xué)院;2011年

，

本文編號：1874139