本文選題：突發(fā)性耳聾　切入點：sVCAM-1　出處：《重慶醫(yī)科大學(xué)》2010年碩士論文　論文類型：學(xué)位論文

【摘要】： 目的 1.檢測突發(fā)性耳聾患者血清中sVCAM-1水平。 2.比較不同狀況下突發(fā)性耳聾患者血清中sVCAM-1表達(dá)情況。 3.探討sVCAM-1在突發(fā)性耳聾發(fā)病中的可能機(jī)制。 方法 采用酶聯(lián)免疫法(ELISA)對58例突發(fā)性耳聾患者(突聾組)及20例健康人員(對照組)血清中sVCAM-1水平進(jìn)行檢測,并分別按照性別、年齡、聽力下降程度、吸煙、飲酒、生活習(xí)慣、發(fā)病前有無上呼吸道感染史以及有無心腦血管合并癥等因素將突發(fā)性耳聾患者分組,采用SPSS17.0統(tǒng)計軟件處理數(shù)據(jù),樣本間比較用t檢驗或one-way ANOVA析,p0.05認(rèn)為有統(tǒng)計學(xué)意義。 結(jié)果 1.突發(fā)性耳聾患者血清中sVCAM-1水平較對照組顯著升高,差異顯著(p0.0001)。 2.中老年突發(fā)性耳聾患者血清中sVCAM-1水平較青年患者顯著升高,差異顯著(p0.05)。 3.發(fā)病前有上呼吸道感染史的突發(fā)性耳聾患者血清中sVCAM-1水平較發(fā)病前無上呼吸道感染史患者顯著升高,差異顯著(p0.05)。 4.有心腦血管合并癥的突發(fā)性耳聾患者血清中sVCAM-1水平較無心腦血管合并癥患者顯著升高,差異顯著(p0.05)。 5.不同性別、聽力下降程度、生活習(xí)慣以及有無吸煙、飲酒史的突發(fā)性耳聾患者血清中sVCAM-1水平無明顯差異(p0.05)。 結(jié)論 1.sVCAM-1可能參與了突發(fā)性耳聾的發(fā)生發(fā)展。 2.年齡、發(fā)病前上呼吸道感染史以及心腦血管合并癥是影響突發(fā)性耳聾患者血清中sVCAM-1水平的重要因素。 3.性別、聽力下降程度、吸煙、飲酒、生活習(xí)慣對突發(fā)性耳聾患者血清中sVCAM-1水平無明顯影響。
[Abstract]:Purpose. 1. The serum sVCAM-1 level was measured in patients with sudden deafness. 2. To compare the expression of sVCAM-1 in serum of patients with sudden deafness. 3. To explore the possible mechanism of sVCAM-1 in the pathogenesis of sudden deafness. Method. The serum levels of sVCAM-1 in 58 patients with sudden deafness (sudden deafness group) and 20 healthy persons (control group) were detected by Elisa. The serum sVCAM-1 levels were determined according to sex, age, degree of hearing loss, smoking, drinking and living habits. The patients with sudden deafness were divided into groups with or without the history of upper respiratory tract infection and cardiovascular and cerebrovascular complications before onset, and the data were processed by SPSS17.0 software. T test or one-way ANOVA analysis (p0.05) were used to compare the data among the samples. Results. 1. The serum sVCAM-1 level in patients with sudden deafness was significantly higher than that in the control group (P 0.0001). 2. The serum sVCAM-1 level in the middle and old patients with sudden deafness was significantly higher than that in the young patients (P 0.05). 3. The serum sVCAM-1 level in patients with sudden deafness with history of upper respiratory tract infection before onset was significantly higher than that in patients with no history of upper respiratory tract infection before onset, and the difference was significant (p 0.05). 4. The level of serum sVCAM-1 in patients with sudden deafness with cardio-cerebrovascular complications was significantly higher than that in patients without cardio-cerebrovascular complications (P 0.05). 5. There was no significant difference in serum sVCAM-1 levels among patients with sudden deafness with different gender, hearing loss, living habits, smoking or drinking history. Conclusion. 1.sVCAM-1 may be involved in the development of sudden deafness. 2. Age, history of upper respiratory tract infection prior to onset and cardiovascular and cerebrovascular complications were important factors affecting serum sVCAM-1 level in patients with sudden deafness. 3. Sex, hearing loss, smoking, drinking and living habits had no significant effect on serum sVCAM-1 level in patients with sudden deafness.
【學(xué)位授予單位】：重慶醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2010
【分類號】：R764

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