本文選題：中重度持續(xù)性　切入點：變應(yīng)性鼻炎　出處：《南京大學(xué)》2013年碩士論文　論文類型：學(xué)位論文

【摘要】：目的：通過鼻激發(fā)試驗(Nasal Provocation Test, NPT)、支氣管激發(fā)試驗(Bronchial Provocation Test, BPT)及鼻灌洗、誘導(dǎo)痰嗜酸性粒細(xì)胞(eosinophils, EOS)計數(shù),分析中重度持續(xù)性變應(yīng)性鼻炎(Allergic Rhinitis, AR)患者鼻與下氣道炎癥特征。 方法：對80名正常對照組、101名中重度持續(xù)性AR患者行NPT、BPT及鼻灌洗、誘導(dǎo)痰EOS計數(shù)。 結(jié)果： 1、AR組基礎(chǔ)肺功能(FVC、FEV1)與對照組相比,差異無統(tǒng)計學(xué)意義(p0.05)； 2、AR組NPT陽性率為75.2%(76/101),與對照組42.5%(34/80)相比,差異有統(tǒng)計學(xué)意義(x2=20.081, p=0.000); 3、AR組BPT陽性率為14.9%(15/101),與對照組2.5%(2/80)相比,差異有統(tǒng)計學(xué)意義(x2=8.003,p0.05), 4、鼻灌洗EOS數(shù)量為22.09±85.3,對照組為0.41±1.27,差異有統(tǒng)計學(xué)意義(t=-10.469,p0.01)； 5、AR組誘導(dǎo)痰EOS數(shù)量為11.02±18.22,對照組為(1.62±2.88)相比,差異有統(tǒng)計學(xué)意義(t=-5.648,p0.01), 6、AR組鼻與下氣道EOS水平存在相關(guān)性(r=0.31,p0.01)。結(jié)論： 1、中重度持續(xù)性AR患者基礎(chǔ)肺功能較正常人無明顯改變； 2、AR患者鼻與下氣道呈現(xiàn)明顯的高反應(yīng)性； 3、AR患者鼻與下氣道存在顯著增高的EOS浸潤； 4、AR以鼻與下氣道EOS浸潤及反應(yīng)性增高為炎癥特征； 5、AR上下氣道炎癥具有一致性； 6、建議AR患者檢查下氣道炎癥狀況,有異常者應(yīng)早期進(jìn)行下氣道干預(yù)。
[Abstract]:Objective: to analyze nasal and inferior airway inflammation in patients with moderate and severe persistent allergic rhinitis (ARs) by nasal stimulation test, nasal stimulation test, bronchial Provocation test and nasal lavage, and count of eosinophils (EOS) in induced sputum eosinophilus (eosinophilus). Methods: 101 patients with moderate or severe persistent AR were treated with NPT, nasal lavage and induced sputum EOS count. Results:. (1) compared with the control group, there was no significant difference in the basic lung function between the AR group and the control group (P 0.05). 2the positive rate of NPT in AR group was 75.2% / 101%, which was significantly higher than that in control group (42.5%) (20.081%) and 0.000% (P < 0.05). 3The positive rate of BPT in AR group was 14. 9% / 101%, which was significantly higher than that in control group (2. 5% / 80). (4) the number of EOS in nasal lavage was 22.09 鹵85.3, that in control group was 0.41 鹵1.27, the difference was statistically significant (P < 0.01). The number of induced sputum EOS was 11.02 鹵18.22 in AR group and 1.62 鹵2.88 in control group. There was a correlation between the EOS level of nasal and lower airway in 6patients with AR. Conclusion:. 1. There was no significant change in basic pulmonary function in moderate and severe persistent AR patients compared with normal controls. 2the nasal and inferior airway showed obvious hyperresponsiveness in patients with AR. 3There were significantly increased EOS infiltration in nose and lower airway in patients with AR. 4AR was characterized by EOS infiltration and increased reactivity in the nasal and lower airway. 5the inflammation of upper and lower airway of AR is consistent; 6. It is suggested that AR patients should check for lower airway inflammation, and early intervention should be carried out in patients with abnormal airway.
【學(xué)位授予單位】：南京大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2013
【分類號】：R765.21

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