發(fā)布時(shí)間：2018-02-14 04:56

  本文關(guān)鍵詞： 受體 白介素4 變應(yīng)性鼻炎 多態(tài)性 基因型　出處：《新疆醫(yī)科大學(xué)》2010年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:變應(yīng)性鼻炎(allergic rhinitis,AR)具有復(fù)雜的遺傳背景,是遺傳因素和環(huán)境因素相互作用的共同結(jié)果,對(duì)該病染色體上易感基因的探究仍然是目前的研究熱點(diǎn)和努力方向。本研究通過分析白細(xì)胞介素4(IL-4)及受體(IL-4R)基因多態(tài)性與維吾爾族(維族)人群AR的關(guān)聯(lián),為探尋AR易感基因和疾病防治提供相關(guān)信息。方法:采用人群為基礎(chǔ)病例對(duì)照研究設(shè)計(jì),以新疆喀什地區(qū)現(xiàn)況調(diào)查發(fā)現(xiàn)的109例維族AR病人和393例健康對(duì)照者為研究對(duì)象,用聚合酶鏈反應(yīng)-限制性片段長度多態(tài)性法(PCR-RFLP)檢測(cè)IL-4 rs2243283C/G和IL-4R rs6498011A/G位點(diǎn)基因多態(tài)性,比較它們?cè)诓±M與對(duì)照組間基因型和等位基因的頻率分布,并通過問卷調(diào)查分析AR相關(guān)影響因素。結(jié)果:(1)IL-4R基因rs6498011A/G位點(diǎn)在病例組和對(duì)照組間基因型分布頻率有統(tǒng)計(jì)學(xué)差異( x 2=23.841,P0.001),等位基因型分布頻率也有統(tǒng)計(jì)學(xué)差異( x 2=7.113,P=0.008),多因素分析結(jié)果同樣顯示IL-4R基因型是AR的影響因素,攜帶IL-4R基因rs6498011位點(diǎn)AA基因型和AG基因型者發(fā)生AR的危險(xiǎn)分別為攜帶GG基因型者的7.330倍、5.316倍。(2)IL-4基因rs2243283C/G位點(diǎn)在兩組間基因型及等位基因分布均無明顯不同(P0.05)。(3)吸煙為新疆喀什地區(qū)維族AR的影響因素,吸煙者發(fā)生AR的危險(xiǎn)性是不吸煙者的2.073倍。結(jié)論: IL-4R基因rs6498011A/G位點(diǎn)基因多態(tài)性與維族AR密切相關(guān),可能是影響維族AR的重要易感侯選基因;IL-4基因rs2243283C/G位點(diǎn)與維族AR無相關(guān)性。
[Abstract]:Objective: allergic rhinitis ARs has a complex genetic background and is a common result of the interaction between genetic and environmental factors. In this study, the polymorphism of interleukin-4 (IL-4) and receptor IL-4R (IL-4R) gene and AR in Uygur nationality (Uygur) population were analyzed, and the relationship between the polymorphisms of IL-4 gene and AR in Uygur population was analyzed by analyzing the relationship between the polymorphism of IL-4 gene and AR in Uygur population. Methods: a population-based case-control study was conducted in 109 Uygur patients with AR and 393 healthy controls in Kashi, Xinjiang. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the polymorphism of IL-4 rs2243283C/G and IL-4R rs6498011A/G loci, and to compare the frequency distribution of genotypes and alleles between case group and control group. Results the frequency of genotype distribution of rs6498011A/G locus of IL-4R gene was significantly different between case group and control group (x2m23. 841, P0.001), and the frequency of allelic genotype was also significantly different (x 2, 7. 113, P < 0. 008, P < 0. 008). The results of factor analysis also showed that IL-4R genotype was the influencing factor of AR. The risk of AR in patients with rs6498011 and AG genotype of IL-4R gene was 7.330-fold and 5.316 times as high as that of those with GG genotype, respectively. There was no significant difference in genotype and allele distribution between the two groups. The influencing factors of Uygur AR in Xinjiang Kashi area, Conclusion: the polymorphism of rs6498011A/G locus of IL-4R gene is closely related to AR in Uygur nationality, and it may be that the rs2243283C/G locus of IL-4 gene, an important susceptible candidate gene, has no correlation with AR in Uygur nationality.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2010
【分類號(hào)】：R765.21

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本文編號(hào)：1509923