本文關鍵詞： 環(huán)加氧酶 咽喉反流 聲門型喉癌　出處：《臨床耳鼻咽喉頭頸外科雜志》2014年06期 　論文類型：期刊論文

【摘要】：目的:探討咽喉反流對環(huán)加氧酶2(COX-2)mRNA在聲門型喉癌病變黏膜中表達的影響。方法:對40例聲門型喉癌患者行電子鼻咽喉鏡檢查、反流檢查計分量表(RFS)和反流癥狀指數量表(RSI)評分,將其分為聲門型喉癌反流陽性組(20例)和聲門型喉癌反流陰性組(20例),另取10例癌旁2cm以上黏膜組織作為對照組。采用Real-time PCR方法,測定各組黏膜中COX-2mRNA的表達情況。結果:聲門型喉癌組COX-2mRNA的表達明顯高于對照組(P0.05);聲門型喉癌反流陽性組的表達高于聲門型喉癌反流陰性組(P0.05)。結論:咽喉反流因素可能通過組織損傷、炎癥及細胞惡性轉化使聲門型喉癌的COX-2mRNA的表達升高。
[Abstract]:Objective: to investigate the effect of laryngeal reflux on the expression of Cyclooxygenase 2OX-2 mRNA in the mucosa of glottic laryngeal carcinoma. Methods: 40 patients with glottic laryngeal carcinoma were examined by electronic nasopharyngoscope. The reflux scoring scale (RFS) and the reflux symptom index (RSI) were divided into two groups: 20 patients with positive reflux of glottic laryngeal carcinoma and 20 patients with negative reflux of glottic laryngeal carcinoma). Another 10 cases of mucosa above 2cm adjacent to carcinoma were taken as control group. Real-time PCR method was used. Results: the expression of COX-2mRNA in glottic laryngeal carcinoma group was significantly higher than that in control group (P 0.05). The expression of reflux positive group in glottic laryngeal carcinoma was higher than that in negative reflux group of glottic laryngeal carcinoma (P 0.05). Conclusion: the factors of pharynx and laryngeal reflux may be caused by tissue injury. Inflammation and malignant cell transformation increase the expression of COX-2mRNA in glottic laryngeal carcinoma.
【作者單位】： 中國醫(yī)科大學附屬盛京醫(yī)院耳鼻咽喉科;
【基金】：遼寧省自然基金(No:20092135) 遼寧省教育廳高校科技研究項目(No:2009A757)
【分類號】：R739.65
【正文快照】： 咽喉反流性疾病(laryngopharyngeal refluxdisease,LPRD)是近年來逐漸被臨床認識的一種多發(fā)病,是指胃內容物反流至食管上括約肌以上部位,通過胃酸膽鹽及胃蛋白酶等直接損傷和刺激迷走神經反射咳嗽導致的機械性損傷所產生的一系列相關疾病。環(huán)加氧酶(cyclooxygenase,COX)是催化

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