【摘要】：目的應(yīng)用RTVue傅里葉域光學(xué)相干斷層掃描（Fourier-domain Optical coherencetomography，F(xiàn)D-OCT)檢測(cè)正常及不同屈光度兒童的視網(wǎng)膜神經(jīng)纖維層（Retinal nerve fiberlayer，RNFL)厚度，探討不同屈光兒童RNFL厚度的分布特點(diǎn)，屈光度和眼軸改變與RNFL厚度的關(guān)系。 方法對(duì)4-15歲兒童(59例男27例40只眼，女32例43只眼)83只眼近視組，其中低度近視組26只眼、中度近視組18只眼、高度近視組17只眼，及22只眼正常對(duì)照組，使用美國(guó)Optovue公司生產(chǎn)的RTVue-FD-OCT分別檢測(cè)平均RNFL厚度和8個(gè)區(qū)域(TU,ST,SN,NU,NL,IN,IT,TL)的RNFL厚度，采用SPSS16.0軟件進(jìn)行統(tǒng)計(jì)分析RNFL厚度分布特點(diǎn)以，采用散點(diǎn)圖分析屈光度和眼軸與RNFL厚度的線性關(guān)系。 結(jié)果正常組平均RNFL厚度：112.77±10.30μm，視盤(pán)周圍8個(gè)區(qū)域(TU,ST,SN,NU,NL,IN,IT,TL)的厚度曲線呈雙駝峰分布，厚度分別為94.13±18.99μm，157.08±22.28μm，157.08±22.28μm，131.50±20.77μm，70.34±13.27μm，65.34±13.91μm，129.71±20.98μm，166.82±20.11μm，88.00±16.95μm，112.87±10.38μm。各近視組平均RNFL厚度分別為：低度近視組106.77±8.60μm，中度近視組101.37±8.88μm，高度近視組85.64±10.58μm，正常對(duì)照組與近視組間統(tǒng)計(jì)學(xué)差異（F=22.860，P=0.000）；八個(gè)區(qū)域中，除TU（F=1.394，P=0.252）及TL（F=2.337，P=0.081）外，其余6區(qū)域組間均有統(tǒng)計(jì)學(xué)意義（F=23.177，P=0.000；F=11.778，P=0.000；F=8.573，P=0.000，F(xiàn)=5.813，P=0.001，，F(xiàn)=5.139，P=0.003，F(xiàn)=11.091，P=0.000，F(xiàn)=22.860，P=0.000）；平均RNFL厚度與屈光度之間關(guān)系：Y=-3.762x+115.3,R=-0.787，P㩳0.05；平均RNFL厚度與眼軸長(zhǎng)度之間關(guān)系：Y=-6.886x+268.4, R=-0.798，P㩳0.05。 結(jié)論正常及屈光不正兒童RNFL厚度曲線均呈雙駝峰分布，以上方及下方為最厚波峰，鼻側(cè)及顳側(cè)最薄為波谷。兒童平均RNFL厚度與屈光度及眼軸長(zhǎng)度呈負(fù)相關(guān)，隨屈光度數(shù)及眼軸的增加而變薄。
[Abstract]:Objective to detect the thickness of retinal nerve fiber layer (Retinal nerve fiberlayer,RNFL) in children with normal and different diopter by RTVue Fourier domain optical coherence tomography (Fourier-domain Optical coherencetomography,FD-OCT), and to explore the distribution characteristics of RNFL thickness in children with different refractive acuity and the relationship between diopter and axial changes and RNFL thickness. Methods 83 eyes of myopia group (59 males, 27 eyes, 40 eyes, female 32 cases, 43 eyes), including 26 eyes in low myopia group, 18 eyes in moderate myopia group, 17 eyes in high myopia group and 22 eyes in normal control group, were used to detect the average RNFL thickness and the RNFL thickness of 8 regions (TU,ST,SN,NU,NL,IN,IT,TL) produced by Optovue Company in the United States. The distribution characteristics of RNFL thickness were statistically analyzed by SPSS16.0 software, and the linear relationship between diopter and eye axis and RNFL thickness was analyzed by scatter plot. Results in the normal group, the average thickness of RNFL was 112.77 鹵10.30 渭 m, and the thickness curve of 8 regions around the optic disc (TU,ST,SN,NU,NL,IN,IT,TL) was double hump distribution, the thickness was 94.13 鹵18.99 渭 m, 157.08 鹵22.28 渭 m, 131.50 鹵20.77 渭 m, 70.34 鹵13.27 渭 m, 65.34 鹵13.91 渭 m, 129.71 鹵20.98 渭 m, 166.82 鹵20.11 渭 m, 88.00 鹵16.95 渭 m, 112.87 鹵10.38 渭 m, respectively. The average RNFL thickness of each myopia group was 106.77 鹵8.60 渭 m in low myopia group, 101.37 鹵8.88 渭 m in moderate myopia group, 85.64 鹵10.58 渭 m in high myopia group, and there was significant difference between normal control group and myopia group (F 鈮

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