【摘要】：目的：通過研究阻塞性睡眠呼吸暫停綜合征(Obstructive Sleep Apnea Syndrome, OSAS)患者血清中白介素-18(IL-18)和單核細胞趨化蛋白-1(MCP-1)水平變化,探討IL-18和MCP-1在OSAS中的作用。 方法：選擇來我院就診的56例OSAS患者和25例健康人,分別作為實驗組和對照組。分別測定實驗組患者術前、術后和對照組的血清中IL-18和MCP-1的水平及其他一般情況(睡眠呼吸暫停低通氣指數(shù)、最低動脈血氧飽和度、收縮壓、舒張壓、脈壓差)的變化。 結果：(1)OSAS患者的脈壓差明顯高于對照組,且隨著OSAS的患病程度加重脈壓差逐漸增高；OSAS患者脈壓差的增高與IL-18和MCP-1水平增高密切相關。(2)OSAS患者血清中IL-18和MCP-1的水平遠遠高于健康人,且OSAS的患病嚴重程度與IL-18和MCP-1水平密切相關,同時IL-18和MCP-1之間存在線性關系；(3)OSAS患者經(jīng)過手術治療后血清中IL-18和MCP-1含量較術前明顯下降。 結論：(1)OSAS患者得心血管疾病的風險明顯高于正常人,且隨著OSAS病情的嚴重程度,患心血管疾病的風險越大,其機制可能與血清中IL-18和MCP-1水平的增高密切相關。(2)血清中IL-18和MCP-1的水平與OSAS的發(fā)病密切相關,并且直接反應了OSAS病情的嚴重程度。
[Abstract]:Objective: to study the changes of serum levels of interleukin-18 (IL-18) and monocyte chemoattractant protein-1 (MCP-1) in patients with obstructive sleep apnea syndrome (Obstructive Sleep Apnea Syndrome, OSAS). To explore the role of IL-18 and MCP-1 in OSAS. Methods: 56 patients with OSAS and 25 healthy persons were selected as experimental group and control group. The serum levels of IL-18 and MCP-1 were measured before, after operation and in the control group (sleep apnea hypopnea index, minimum arterial oxygen saturation, systolic blood pressure, diastolic blood pressure), and other general conditions (sleep apnea hypopnea index, minimum arterial oxygen saturation, systolic blood pressure, diastolic blood pressure). Pulse pressure difference). Results: (1) the pulse pressure difference of OSAS patients was significantly higher than that of the control group, and gradually increased with the severity of OSAS. The increase of pulse pressure difference in OSAS patients was closely related to the increase of IL-18 and MCP-1 levels. (2) the levels of IL-18 and MCP-1 in the serum of OSAS patients were much higher than those of healthy people, and the severity of OSAS was closely related to the levels of IL-18 and MCP-1. At the same time, there is a linear relationship between IL-18 and MCP-1. (3) the levels of IL-18 and MCP-1 in serum of OSAS patients were significantly lower than those before operation. Conclusion: (1) the risk of cardiovascular disease in OSAS patients is significantly higher than that in normal controls, and the risk of cardiovascular disease increases with the severity of OSAS. The mechanism may be closely related to the increase of IL-18 and MCP-1 in serum. (2) the levels of IL-18 and MCP-1 in serum are closely related to the pathogenesis of OSAS and directly reflect the severity of OSAS.
【學位授予單位】：山東大學
【學位級別】：碩士
【學位授予年份】：2012
【分類號】：R766

【參考文獻】

相關期刊論文 前10條

1 侯冬青;王湘富;楊輝紅;李朝霞;李雙娥;李佩凡;彭紅霞;;阻塞性睡眠呼吸暫停低通氣綜合征的臨床流行病學調查及相關因素分析[J];醫(yī)學臨床研究;2006年03期

2 劉杰,孫晗笑;單核細胞趨化蛋白-1生物學特性及應用研究[J];生命的化學;2001年06期

3 慈書平;張希龍;戴煌;楊春雷;胡仁學;;老年睡眠呼吸暫停綜合征與糖尿病關系的流行病學調查[J];實用老年醫(yī)學;2007年01期

4 程英;張錦;周緯;張紅;;寧夏地區(qū)鼾癥及OSAHS的現(xiàn)況調查[J];寧夏醫(yī)科大學學報;2009年05期

5 邱永亮;鐘純;楊啟明;藍志德;羅秋萍;;低溫等離子射頻治療阻塞性睡眠呼吸暫停低通氣綜合征療效評價[J];中國中西醫(yī)結合耳鼻咽喉科雜志;2006年01期

6 王強;王蓓;劉卓拉;;阻塞性睡眠呼吸暫停低通氣綜合征患者心血管疾病相關因子血清水平的變化分析[J];中國循環(huán)雜志;2009年06期

7 中華醫(yī)學會呼吸病學分會睡眠呼吸疾病學組;阻塞性睡眠呼吸暫停低通氣綜合征診治指南(草案)[J];中華結核和呼吸雜志;2002年04期

8 上海市醫(yī)學會呼吸病學分會睡眠呼吸疾病學組;上海市30歲以上人群阻塞性睡眠呼吸暫停低通氣綜合征流行病學調查[J];中華結核和呼吸雜志;2003年05期

9 張慶,何權瀛,杜秋艷,龐桂芬,趙立雙,吳瑞芹,韓芳,劉李承,王英,孫桂香,劉曉燕,趙志偉;承德市區(qū)居民睡眠呼吸暫停低通氣綜合征患病率入戶調查[J];中華結核和呼吸雜志;2003年05期

10 張慶泉,張杰,李樹峰;Endoscope-assisted repair of large nasal septal perforation using a complex mucoperichondrial flap and free tissue graft[J];Chinese Medical Journal;2003年01期

，

本文編號：2318705