【摘要】：目的：通過以自體髂骨組織為支架的人工角膜植入重度堿燒傷兔眼的實驗,探討自體骨組織為支架的人工角膜治療重度堿燒傷兔眼的可行性,包括該型人工角膜的設(shè)計合理性、生物相容性、移植手術(shù)的方式以及并發(fā)癥。 方法：重度堿燒傷兔眼的模型制作三個月后,將PMMA光學(xué)柱鏡埋入兔髂骨三個月后,取出塑形制作成自體髂骨及骨膜組織為支架的人工角膜模型9例；將制成的人工角膜模型植入重度堿燒傷兔眼,進行實驗觀察。 結(jié)果：重度堿燒傷兔眼的模型制作順利。自體髂骨為支架的人工角膜手術(shù)過程基本順利完成,術(shù)中1例在行PMMA柱鏡并周圍髂骨組織取出術(shù)時發(fā)現(xiàn)柱鏡脫離。高度懷疑柱鏡在埋入后未固定牢固,導(dǎo)致脫離。1例術(shù)后傷口感染合并肺部感染死亡。其余8例手術(shù)順利。在觀察期內(nèi),2例人工角膜排出,余6例未見人工角膜支架溶解、房水滲漏、高眼壓人工角膜排出及感染等并發(fā)癥,人工角膜在眼部穩(wěn)定存在3個月以上。 結(jié)論： 1、以PMMA為光學(xué)柱鏡以自體髂骨為支架的人工角膜,設(shè)計基本合理,可以長期存在重度堿燒傷的兔眼,為臨床治療重度堿燒傷提供重要支持； 2、此型人工角膜移植手術(shù)方式,操作簡單,術(shù)中及術(shù)后并發(fā)癥相對較小； 3、通過本實驗觀察表明此型人工角膜具有實際臨床應(yīng)用的可行性,為進一步的動物實驗提供理論依據(jù)及技術(shù)支持。
[Abstract]:Objective: to investigate the feasibility of using autogenous iliac tissue as scaffold in the treatment of severe alkali burn rabbit eyes, including the rationality of the design of this type of corneal artificial cornea. Biocompatibility, transplant procedures, and complications. Methods: the rabbit model of severe alkali burn was made three months later. The PMMA optical post microscope was implanted into the iliac bone of the rabbit for 3 months. The model of autogenous iliac bone and periosteal tissue was taken out and made into an artificial cornea model of 9 cases. The model of artificial cornea was implanted into the rabbit eyes of severe alkali burn, and the experimental observation was carried out. Results: the model of severe alkali burn rabbit eyes was made smoothly. The procedure of autogenous iliac graft artificial keratoplasty was basically completed successfully. One case was found to be detached from the post during the operation of PMMA and the removal of the surrounding iliac bone. Highly suspected post-endoscopy was not firmly fixed after implantation, resulting in detachment. 1 case died of postoperative wound infection with pulmonary infection. The other 8 cases were successfully operated. During the observation period, 2 cases of artificial cornea ejected, the remaining 6 cases did not see complications such as stent dissolution, aqueous humor leakage, high intraocular pressure artificial cornea excretion and infection. The artificial cornea remained stable in the eye for more than 3 months. Conclusion: 1. The design of artificial cornea with PMMA as optical pillar mirror and autogenous iliac bone as scaffold is reasonable and can provide important support for clinical treatment of severe alkali burn. 2. This type of keratoplasty is easy to operate, and has relatively small complications during and after operation. 3. The experimental results show that this type of corneal prosthesis has the feasibility of clinical application and provides theoretical basis and technical support for further animal experiments.
【學(xué)位授予單位】：昆明醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R779.65

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