【摘要】：目的:探討變應(yīng)性鼻炎(AR)患者外周血嗜酸粒細(xì)胞(EOS)計(jì)數(shù)與IL-33水平的關(guān)系及未經(jīng)任何治療的AR患者(A組)、經(jīng)皮下免疫治療至少1年后AR患者(B組)、經(jīng)皮下免疫治療至少1年后伴變應(yīng)性哮喘(AA)的AR患者(C組)這3組的IL-33水平、嗜酸粒細(xì)胞計(jì)數(shù)、視覺(jué)模擬評(píng)分(VAS)的關(guān)系。方法:選取20例健康者作為對(duì)照組參與實(shí)驗(yàn),所有受試者行血細(xì)胞分析,統(tǒng)計(jì)嗜酸粒細(xì)胞數(shù)量。采用酶聯(lián)免疫(ELISA)檢測(cè)外周血IL-33水平,所得數(shù)據(jù)用GraphPad.Prism 5.0與SPSS 22.0處理。AR患者行VAS評(píng)分并評(píng)估鼻部癥狀。結(jié)果:A組IL-33水平高于其他組IL-33水平(P0.05);B組IL-33水平與C組IL-33水平相比,差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05);B組和C組IL-33水平均高于對(duì)照組IL-33水平(P0.05);A組嗜酸粒細(xì)胞計(jì)數(shù)高于其他組,各組間相互比較嗜酸粒細(xì)胞計(jì)數(shù)差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05);A組VAS評(píng)分高于B組VAS評(píng)分(P0.05);A組VAS評(píng)分與C組VAS評(píng)分比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05);B組VAS評(píng)分與C組VAS評(píng)分比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。經(jīng)皮下免疫治療(SCIT)至少1年后AR患者自覺(jué)鼻塞、流清涕、打噴嚏等癥狀均有明顯減輕。Spearman檢驗(yàn)AR患者IL-33水平與嗜酸粒細(xì)胞計(jì)數(shù)呈弱正相關(guān)(P0.05,r=0.287)。結(jié)論:SCIT對(duì)AR療效明顯,可緩解患者臨床癥狀,還可降低患者IL-33水平和外周血嗜酸粒細(xì)胞計(jì)數(shù)。
[Abstract]:Objective: to investigate the relationship between eosinophil (EOS) count and IL-33 level in peripheral blood of patients with allergic rhinitis (AR) and the patients with AR without any treatment (group A), AR patients (group B) after subcutaneous immunotherapy for at least one year, and subcutaneous immunotherapy. At least a year later, the IL-33 levels in the three groups of AR patients with allergic asthma with (AA) (group C), The relationship between eosinophil count and visual analogue score (VAS). Methods: 20 healthy subjects were selected as control group. All subjects were analyzed with blood cells to count the number of eosinophils. The level of IL-33 in peripheral blood was detected by Elisa (ELISA). The data were treated with GraphPad.Prism 5.0 and SPSS 22.0. VAS score and nasal symptoms were evaluated in AR patients. Results: the level of IL-33 in group A was higher than that in other groups (P0.05 IL-33 level in); B group was higher than IL-33 level in C group (P0.05) IL-33 level in); B group and C group was higher than that in control group (P05); A group was higher than other groups in eosinophil count. There was no significant difference in eosinophil count between each group (P0.05); A group VAS score was higher than B group VAS score (P0.05); A group VAS score and C group VAS score difference was not statistically significant (P0.05); B group VAS score and C group VAS score comparison no significant difference (P0.05). After subcutaneous immunotherapy for at least one year, the symptoms of AR patients such as nasal obstruction, snot and sneezing were significantly alleviated. Spearman test showed a weak positive correlation between IL-33 level and eosinophil count in AR patients (P 0.05 rr 0.287). Conclusion: SCIT is effective in treating AR. It can relieve clinical symptoms, decrease IL-33 level and eosinophil count in peripheral blood.
【作者單位】： 廣西中醫(yī)藥大學(xué)研究生學(xué)院;廣西壯族自治區(qū)人民醫(yī)院耳鼻咽喉科;
【基金】：國(guó)家自然科學(xué)基金資助項(xiàng)目(No:81460097) 廣西自然科學(xué)基金(No:2017JJA140333Z) 廣西壯族自治區(qū)衛(wèi)生廳自籌經(jīng)費(fèi)科研課題(No:Z2016643)
【分類號(hào)】：R765.21

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