【摘要】：目的:通過觀察鼻咽癌患者在治療前凝血功能相關(guān)指標(biāo)(PLT、APTT、PT、TT、FIB)在不同性別、年齡、分期、分化程度及轉(zhuǎn)移情況下的變化,探討其臨床意義,為早期預(yù)防血栓栓塞形成和早期使用預(yù)防性抗凝藥物治療提供新的思路和理論依據(jù)。方法:選取2016年01月至2017年01月期間就診于貴州省腫瘤醫(yī)院頭頸腫瘤科或耳鼻喉科,經(jīng)病理活檢確診為鼻咽癌且未經(jīng)過放療、化療等治療的患者共計132例(男99例,女33例),并選取同期于貴州省腫瘤醫(yī)院健康體檢中心體檢的健康體檢者68例作為對照組,記錄鼻咽癌組和對照組外周血PLT、APTT、PT、TT、FIB,運用SPSS22.0統(tǒng)計軟件進(jìn)行相關(guān)分析。結(jié)果:1.鼻咽癌組外周血中PLT、APTT、FIB水平明顯高于健康對照組(P0.05),PT、TT兩組間差異無統(tǒng)計學(xué)意義(P0.05);2.鼻咽癌APTT、PT男性組較女性組延長(P0.05);PLT、TT、FIB兩組間差異無統(tǒng)計學(xué)意義(P0.05);3.鼻咽癌小于等于50歲組PLT、APTT、PT水平明顯高于大于50歲組(P0.05),TT水平低于大于50歲組(P0.05);FIB兩組間差異無統(tǒng)計學(xué)意義(P0.05);4.鼻咽癌組PLT、APTT、FIB水平與T分期、N分期、臨床分期有關(guān),分期越晚,水平升高越明顯(P0.05);PT、TT與T分期、N分期及臨床分期之間無明顯差異(P0.05);5.鼻咽癌Ⅳ期非遠(yuǎn)處轉(zhuǎn)移組PLT、FIB水平明顯低于遠(yuǎn)處轉(zhuǎn)移組(P0.05);而APTT、PT、TT兩組間無明顯差異(P0.05)。6.鼻咽癌PLT、APTT、PT、TT及FIB水平在非角化分化型與非角化未分化型之間均無明顯差異(P0.05);7.鼻咽癌組FIB與T分期、N分期、臨床分期及遠(yuǎn)處轉(zhuǎn)移呈正相關(guān),PLT與遠(yuǎn)處轉(zhuǎn)移呈正相關(guān),具有統(tǒng)計學(xué)意義(P0.05);PLT與T分期、N分期、臨床分期無相關(guān)性(P0.05);APTT、PT、TT與T分期、N分期、臨床分期及遠(yuǎn)處轉(zhuǎn)移均無相關(guān)性(P0.05)。結(jié)論:1.鼻咽癌患者外周血PLT、FIB水平明顯高于健康對照組,提示鼻咽癌患者體內(nèi)存在不同程度的高凝狀態(tài);2.鼻咽癌患者外周血中FIB水平與T分期、N分期、臨床分期及遠(yuǎn)處轉(zhuǎn)移呈正相關(guān),PLT與遠(yuǎn)處轉(zhuǎn)移情況呈正相關(guān),發(fā)生遠(yuǎn)處轉(zhuǎn)移者,高凝狀態(tài)更加顯著,提示鼻咽癌晚期發(fā)生血檢的風(fēng)險增加。
[Abstract]:Objective: to observe the changes of coagulation function related index (PLT,APTT,PT,TT,FIB) in patients with nasopharyngeal carcinoma (NPC) before treatment under different sex, age, stage, differentiation and metastasis, and to explore its clinical significance. To provide new ideas and theoretical basis for early prevention of thromboembolism and early use of prophylactic anticoagulant therapy. Methods: from January 2016 to January 2017, 132 patients (99 males) with nasopharyngeal carcinoma (NPC) confirmed by pathological biopsy without radiotherapy and chemotherapy were selected from head and neck oncology department or otolaryngology department of Guizhou Provincial Oncology Hospital from January 2016 to January 2017. In this study, 68 healthy persons from the center of health examination of Guizhou Provincial Cancer Hospital were selected as the control group. The peripheral blood PLT,APTT,PT,TT,FIB, of nasopharyngeal carcinoma group and control group were recorded and analyzed by SPSS22.0 statistical software. The result is 1: 1. The level of PLT,APTT,FIB in peripheral blood of nasopharyngeal carcinoma group was significantly higher than that of healthy control group (P0.05). There was no significant difference between the two groups (P0.05). The APTT,PT of nasopharyngeal carcinoma in male group was longer than that in female group (P0.05). There was no significant difference between the two groups (P0.05). The PLT,APTT,PT level of NPC < 50 years old group was significantly higher than that of more than 50 years old group (P0.05). There was no significant difference between the two groups (P0.05). The level of PLT,APTT,FIB in nasopharyngeal carcinoma group was related to T staging and N stage. The later the stage was, the higher the level was (P0.05). There was no significant difference between PTT TT and T staging and N stage and clinical stage (P0.05). The PLT,FIB level of NPC stage 鈪，

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