本文選題：麻醉藥 + 水合氯醛��； 參考：《聽力學(xué)及言語疾病雜志》2017年02期

【摘要】：目的探討水合氯醛麻醉對(duì)成年豚鼠聽性腦干反應(yīng)檢測的影響。方法分別在清醒狀態(tài)(waking state,W)及水合氯醛(chloral hydrate,CH)麻醉狀態(tài)下對(duì)20只健康成年雄性白色豚鼠進(jìn)行短聲(click)誘發(fā)的聽性腦干反應(yīng)(auditory brainstem response,ABR)檢測,以引出率最高的波來判斷反應(yīng)閾值,比較兩種狀態(tài)下90dB peSPL刺激聲強(qiáng)下ABR各波的潛伏期、波間期及不同強(qiáng)度下的Ⅱ、Ⅲ、Ⅳ波振幅及引出率。結(jié)果 20只豚鼠水合氯醛麻醉狀態(tài)與清醒狀態(tài)下ABR反應(yīng)閾分別為25.50±2.76、28.5±3.66dB peSPL,差異無統(tǒng)計(jì)學(xué)意義(P0.05)。水合氯醛麻醉狀態(tài)下ABR各波潛伏期較清醒狀態(tài)均延長,Ⅲ、Ⅳ、Ⅴ波差異有統(tǒng)計(jì)學(xué)意義(P0.05),而Ⅰ、Ⅱ波差異無統(tǒng)計(jì)學(xué)意義(P0.05);水合氯醛麻醉狀態(tài)下Ⅰ-Ⅴ、Ⅲ-Ⅳ、Ⅳ-Ⅴ波間期較清醒狀態(tài)下延長(P0.05),而Ⅰ-Ⅱ、Ⅱ-Ⅲ波間期差異無統(tǒng)計(jì)學(xué)意義(P0.05);水合氯醛麻醉狀態(tài)和清醒狀態(tài)均顯示波Ⅱ振幅及引出率最高;水合氯醛麻醉狀態(tài)波Ⅱ、Ⅲ振幅在高強(qiáng)度刺激聲時(shí)較清醒狀態(tài)高,而波Ⅳ振幅較清醒狀態(tài)低(P0.05)。結(jié)論水合氯醛麻醉及清醒狀態(tài)下豚鼠ABR反應(yīng)閾無明顯差異,但水合氯醛麻醉會(huì)使豚鼠ABR的波Ⅲ、Ⅳ、Ⅴ潛伏期明顯延長,并對(duì)振幅產(chǎn)生影響;豚鼠ABR波Ⅱ出現(xiàn)率最高,可以Ⅱ波判斷反應(yīng)閾。
[Abstract]:Objective to investigate the effect of chloral hydrate anesthesia on auditory brainstem response in adult guinea pigs. Methods A total of 20 healthy adult male white guinea pigs were subjected to auditory brainstem response (ABR) under anaesthesia of chloral anaesthesia and chloral anaesthesia. The auditory brainstem response (ABR) was measured by auditory brainstem response (ABR) in 20 healthy adult male guinea pigs. The highest response threshold was determined by the highest extraction rate. The latencies of ABR waves, the amplitudes of wave 鈪，

本文編號(hào)：1997279