本文選題：開角型青光眼 + 高眼壓癥�。� 參考：《寧夏醫(yī)科大學(xué)》2012年碩士論文

【摘要】：目的觀察真空小梁成形術(shù)（PNT）治療原發(fā)性開角型青光眼和高眼壓癥患者的療效和安全性。 方法寧夏眼科醫(yī)院就診的原發(fā)性開角型青光眼和高眼壓癥患者30眼(21例)，進(jìn)行視力，屈光度，中央角膜厚度、眼壓，，裂隙燈，前房角鏡、眼底、視盤OCT及Humphrey自動(dòng)視野計(jì)等全面眼科檢查。所有患者簽署知情同意書后行PNT1000型治療儀（Ophthalmic International公司產(chǎn)）治療，為鞏固降眼壓作用，一般在首次治療后第七天重復(fù)治療一次。首次治療后1小時(shí)、1天、1周、2周、1個(gè)月、2個(gè)月、3個(gè)月復(fù)查，觀察眼壓、并發(fā)癥及抗青光眼藥物種類等情況。 結(jié)果30眼患者治療前眼壓23.3±1.7mmHg，治療后1天、1周、2周、1個(gè)月、2個(gè)月、3個(gè)月各時(shí)間點(diǎn)眼壓分別為19.7±4.0mmHg、19.7±2.8mmHg、19.4±4.1mmHg、19.0±2.4mmHg、18.6±3.3mmHg、18.4±3.0mmHg，各時(shí)間點(diǎn)較治療前基線眼壓差異有統(tǒng)計(jì)學(xué)意義（P均0.001），25眼（83.3%）治療后平均眼壓下降幅度超過15%。使用抗青光眼藥物（1到3種）的16眼，PNT治療后3個(gè)月眼壓與基線相比平均下降3.9mmHg (P0.05)，用藥種類出現(xiàn)減少趨勢(shì)。30眼在PNT治療后僅出現(xiàn)結(jié)膜充血、水腫，結(jié)膜下出血，一過性視物模糊及異物感等輕微反應(yīng)，三個(gè)月內(nèi)最佳矯正視力、視網(wǎng)膜神經(jīng)纖維層厚度及視神經(jīng)未出現(xiàn)明顯變化（p＞0.05）。 結(jié)論本研究短期小樣本證實(shí)PNT可以安全有效地降低原發(fā)性開角型青光眼和高眼壓癥患者的眼壓，尤其對(duì)使用多種眼表降眼壓藥物、依存性差及無(wú)法耐受手術(shù)及激光的患者，PNT也可作為一種簡(jiǎn)單、無(wú)創(chuàng)的輔助降眼壓方法。
[Abstract]:Objective to observe the efficacy and safety of vacuum trabeculoplasty (PNTs) in the treatment of primary open angle glaucoma and ocular hypertension. Methods 30 eyes of 21 patients with primary open angle glaucoma and high intraocular pressure were treated with visual acuity, diopter, central corneal thickness, intraocular pressure, slit lamp, anterior chamber angle lens, fundus. Optic disc OCT and Humphrey automatic visual field meter and other comprehensive ophthalmic examination. All patients were treated with PNT1000 Ophthalmic International after signing informed consent. In order to consolidate the effect of intraocular pressure reduction, they were treated repeatedly on the seventh day after the first treatment. The intraocular pressure, complications and kinds of antiglaucoma drugs were observed after 1 hour, 1 day, 1 week, 1 month, 2 months and 3 months after the first treatment. Results the IOP of 30 eyes before treatment was 23.3 鹵1.7mmHg, and the IOP was 19.7 鹵4.0mmHg 19.4 鹵4.1mmHg 19.0 鹵2.4mmHg 18.6 鹵3.3mm Hg 18.6 鹵3.3mmHg at each time point after treatment. There were significant differences in IOP between two weeks and two weeks, one month, two months, two months and three months after treatment. The drop in intraocular pressure was more than 15. The intraocular pressure (IOP) of 16 eyes treated with antiglaucoma drugs (1 to 3) decreased on average 3 months after treatment compared with baseline. There was a decreasing trend of drug use. 30 eyes showed conjunctival hyperemia, edema and subconjunctival hemorrhage after PNT treatment. There were no obvious changes in the thickness of retinal nerve fiber layer and optic nerve in three months after the slight reaction such as transient blurred vision and foreign body sensation (P > 0.05). Conclusion this study demonstrated that PNT can reduce intraocular pressure safely and effectively in patients with primary open angle glaucoma and high intraocular pressure, especially in patients with multiple ocular surface pressure lowering drugs. PNT can also be used as a simple, non-invasive assistant method for lowering IOP in patients with poor dependence and intolerable operation and laser.
【學(xué)位授予單位】：寧夏醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類號(hào)】：R775

【參考文獻(xiàn)】

相關(guān)期刊論文 前2條

1 方敏,余敏斌;高眼壓癥認(rèn)識(shí)新進(jìn)展[J];國(guó)外醫(yī)學(xué)(眼科學(xué)分冊(cè));2004年05期

2 曹麗輝;楊笑天;王玉清;;PNT治療原發(fā)性開角型青光眼及高眼壓癥的臨床觀察[J];黑龍江醫(yī)藥科學(xué);2011年02期

相關(guān)碩士學(xué)位論文 前1條

1 劉洪;超聲乳化聯(lián)合小梁切除與聯(lián)合房角分離術(shù)治療急性閉角型青光眼合并白內(nèi)障的療效[D];重慶醫(yī)科大學(xué);2011年

本文編號(hào)：1901594