本文選題：Graves眼病　切入點：IL-　出處：《中國煤炭工業(yè)醫(yī)學(xué)雜志》2017年04期 　論文類型：期刊論文

【摘要】：目的通過檢測Graves眼病患者外周血IL-17、IL-21表達水平,探討IL-17、IL-21與Graves眼病及甲狀腺功能的相關(guān)性。方法觀察組為50例初診Graves眼病患者,對照組為50例健康人,檢測二組外周血中IL-17、IL-21水平及甲狀腺功能。結(jié)果采用獨立樣本t檢驗及相關(guān)性分析。結(jié)果觀察組外周血IL-17濃度(1 546.52±806.87)pg/ml、IL-21濃度(884.30±444.37)pg/ml較對照組IL-17濃度(770.82±437.03)pg/ml、IL-21濃度(522.38±261.15)pg/ml明顯增高(P0.05)。觀察組經(jīng)Pearson相關(guān)性分析,IL-17與TT3呈正相關(guān)(r=0.459,P=0.012);IL-21與TT3、FT4呈正相關(guān)(r=0.492,0.372,P=0.007,0.047)。結(jié)論 Graves眼病患者外周血IL-17、IL-21水平顯著升高并與TT3呈正相關(guān),IL-17、IL-21可能與Graves眼病的發(fā)生和發(fā)展相關(guān)。
[Abstract]:Objective to investigate the correlation between IL-17 and IL-21 in peripheral blood of patients with Graves ophthalmopathy and Graves ophthalmopathy and thyroid function. Results the levels of IL-17, IL-21 and thyroid function in peripheral blood of the two groups were determined by independent sample t-test and correlation analysis. Results the concentration of IL-21 in peripheral blood of the observation group was significantly higher than that of the control group. The concentration of IL-21 in peripheral blood was (1 546.52 鹵806.87) 渭 g / ml, 884.30 鹵444.37 渭 g / ml and (770.82 鹵437.03pg / ml), 522.38 鹵261.15 渭 g / ml and 522.38 鹵261.15 渭 g / ml, respectively. There was a positive correlation between IL-17 and TT3 by Pearson correlation between IL-21 and TT3FT4. Conclusion the level of IL-17 and IL-21 in peripheral blood of Graves patients with ophthalmopathy may be positively correlated with the occurrence and development of Graves ophthalmopathy.
【作者單位】： 重慶醫(yī)科大學(xué)附屬永川醫(yī)院;
【基金】：重慶市衛(wèi)生和計劃生育委員會醫(yī)學(xué)科研項目(編號:2013-2-072)
【分類號】：R581.1;R771.3

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