Mice carrying Collagen2a1-cre-mediated deletions of Lrp5 and/or Lrp6 were created and characterized.Mice lacking either gene alone were viable and fertile with normal knee morphology.Mice in which both Lrp5 and Lrp6 were conditionally ablated via Collagen2al-cre-mediated deletion displayed severe defects in skeletal development during embryogenesis.In addition,adult mice carrying Collagen2al-cre-mediated deletions of Lrp5 and/or Lrp6 displayed low bone mass suggesting that the Collagen2a1-cre tr... 

【文章來源】：Bone Research. 2015,3(04)SCICSCD

【文章頁數(shù)】：11 頁

【參考文獻】：
期刊論文
[1]LRP6 in mesenchymal stem cells is required for bone formation during bone growth and bone remodeling[J]. Changjun Li,Bart O Williams,Xu Cao,Mei Wan.  Bone Research. 2014(01)
[2]A Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice[J]. Kevin A.Maupin,Casey J.Droscha,Bart O.Williams.  Bone Research. 2013(01)



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