B細(xì)胞的CD40/CD40配體（CD40/CD40L）系統(tǒng)在機(jī)體體液免疫中發(fā)揮重要作用,主要是通過(guò)影響B(tài)細(xì)胞的存活、增殖、分化、免疫球蛋白類(lèi)別轉(zhuǎn)換等B細(xì)胞的功能,進(jìn)而影響體液免疫的平衡。B細(xì)胞CD40信號(hào)的活化能加強(qiáng)B細(xì)胞存活并促進(jìn)B細(xì)胞增殖,CD40/CD40L系統(tǒng)亦能影響B(tài)細(xì)胞向漿細(xì)胞分化,CD40L缺陷導(dǎo)致的CD40/CD40L系統(tǒng)異常,使B細(xì)胞不能發(fā)生正常的免疫球蛋白類(lèi)別轉(zhuǎn)換而積累大量Ig M。本文總結(jié)了CD40/CD40L系統(tǒng)對(duì)B細(xì)胞功能的影響。 

【文章來(lái)源】：細(xì)胞與分子免疫學(xué)雜志. 2015,31(05)北大核心CSCD

【文章頁(yè)數(shù)】：4 頁(yè)

【文章目錄】：
1 CD40 與 CD40L
2CD40信號(hào)通路
3CD40/CD40L系統(tǒng)對(duì)B細(xì)胞的作用
    3.1CD40/CD40L系統(tǒng)促進(jìn)B細(xì)胞的存活和增殖
    3.2CD40信號(hào)對(duì)B細(xì)胞分化的作用
    3.3CD40/CD40L系統(tǒng)對(duì)B細(xì)胞免疫球蛋白類(lèi)別轉(zhuǎn)換的作用
    3.4抑制B細(xì)胞凋亡
4小結(jié)與展望


【參考文獻(xiàn)】：
期刊論文
[1]小鼠CD40分子胞外段基因的克隆、原核表達(dá)及活性鑒定[J]. 田仁禮,朱靜瀠,殷小濤,王偉,林曉亮,徐元基,閻瑾琦,張巍,高江平,于繼云.  細(xì)胞與分子免疫學(xué)雜志. 2013(11)
[2]CD40-CD40L共刺激途徑在體液免疫和細(xì)胞免疫中的作用[J]. 杜振蘭.  細(xì)胞與分子免疫學(xué)雜志. 2012(12)
[3]CD40/CD40L Dyad in the Inflammatory and Immune Responses in the Central Nervous System[J]. Keqiang Chen, Jian Huang, Wanghua Gong, Lingzhi Zhang, Peichu Yu and Ji Ming Wang School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 201101, China; Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA; Basic Research Program, SAIC-Frederick, National Cancer Institute at Frederick, Frederick, MD 21702, USA.  Cellular & Molecular Immunology. 2006(03)



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