目的 研究下丘腦室旁核（hypothalamic paraventricular nucleus,PVN）內注射谷氨酸（glutamate,Glu）對慢性內臟高敏感性（chronic visceral hypersensitivity,CVH）大鼠慢性內臟痛的影響及其可能的機制。方法 新生SD大鼠,在出生后第8、10、12天分別給予結直腸擴張法制備CVH大鼠模型。取30只制備成功的CVH模型大鼠,隨機分為CVH模型組（CVH組）、CVH＋PVN內注射生理鹽水組（NS組）、CVH＋PVN內注射Glu組3、6、12 μg組（G3組、G6組、G12組）,每組6只,另取體質量相匹配的6只SD大鼠作為假手術組（Sham組）。采用痛閾、腹壁撤退反射（abdominal withdrawal reflex,AWR）評分和腹外斜肌肌電圖（abdominal external oblique muscle electromyography,EMG）評價大鼠的痛行為。免疫組化染色法檢測大鼠腦內精氨酸加壓素（arginine vasopressin,AVP）表達水平和結腸組織細胞增殖情況,Tunel法檢測結... 

【文章來源】：中華行為醫(yī)學與腦科學雜志. 2019,(09)

【文章頁數】：6 頁

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