13-Methyltetradecanoic acid can stabilize cell membrane and have anti-inflammatory,antioxidant and anti-apoptotic effects.Previous studies mainly focused on peripheral nerve injury,but seldom on the central nervous system.We investigated whether these properties of 13-methyltetradecanoic acid have a neuroprotective effect on focal cerebral ischemia/reperfusion injury,and detected the expression of basic fibroblast growth factor and vascular endothelial growth factor.This study established rat mo...

【文章頁(yè)數(shù)】：7 頁(yè)

【文章目錄】：
Introduction
Materials and Methods
    Animals
    Middle cerebral artery occlusion/reperfusion (MCAO/R) modeling
    Administration of drugs
    Measurement of infarct volume and cerebral edema analysis
    Cerebral edema analysis
    Blood-brain barrier (BBB) permeability detection
    Reverse transcription-polymerase chain reaction (RT-PCR)
    Immunohistochemistry of b FGF and VEGF
    Statistical analysis
Results
    Changes in infarct volume and cerebral edema after ischemia/reperfusion injury
    Evans blue content in brain tissue of rats with ischemia/reperfusion injury
    Expression of b FGF and VEGF m RNA in brain tissue of rats with ischemia/reperfusion injury
    Immunoreactivities of b FGF and VEGF in brain tissue of rats with ischemia/reperfusion injury
Discussion



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