Nicotiflorin is a flavonoid extracted from Carthamus tinctorius.Previous studies have shown its cerebral protective effect,but the mechanism is undefined.In this study,we aimed to determine whether nicotiflorin protects against cerebral ischemia/reperfusion injury-induced apoptosis through the JAK2/STAT3 pathway.The cerebral ischemia/reperfusion injury model was established by middle cerebral artery occlusion/reperfusion.Nicotiflorin(10 mg/kg) was administered by tail vein injection.Cell apoptos...

【文章頁(yè)數(shù)】：7 頁(yè)

【文章目錄】：
Graphical Abstract
Introduction
Materials and Methods
    Animals
    Surgical operation
    Drug administration
    Brain tissue extraction
    Hematoxylin-eosin staining
TUNEL assay
    Immunohistochemical staining
    Western blot assay
    Statistical analysis
Results
    Nicotiflorin inhibited neuronal pathological changes
    Nicotiflorin decreased cerebral I/R-induced cell apoptosis
    Nicotiflorin inhibited JAK2 and STAT3 phosphorylation
    Nicotiflorin altered caspase-3,Bcl-2,and Bax immunoreactivity
Discussion



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