目的:帕金森氏病(PD)是老年人中普遍存在的一種神經(jīng)退行性疾病。體重指數(shù)(BMI)較高的患者中發(fā)病率較高,而一些報告則指出肥胖是帕金森氏病的危險因素。診斷時患有帕金森病的患者的BMI高于正常水平,隨著疾病的發(fā)展,其BMI會低于正常水平。因此,有必要在肥胖,生活方式,遺傳學(xué),代謝綜合征和帕金森氏病(PD)風(fēng)險之間建立關(guān)聯(lián)。因此,有必要建立肥胖、生活方式、遺傳、代謝綜合征與帕金森病風(fēng)險之間的相關(guān)性方法:在這項(xiàng)研究中,從2014年01月到2018年12月,江蘇大學(xué)附屬人民醫(yī)院共選拔了349名帕金森病門診病人和住院病人,同期有74名非腦血管病住院病人,被選為控制組。根據(jù)Hoehn-Yahr等級,帕金森氏癥患者分為早期(1²級)、中級(2.5³級)和晚期(4⁵級)。測量并記錄了身高、體重、腰圍和臀部周長、總膽固醇(TC)、總甘油(TG)、高密度脂蛋白膽固醇(HDL-C)和低密度脂蛋白膽固醇(LDL-C)。還評估了帕金森病的嚴(yán)重程度與血脂之間的關(guān)系。結(jié)果:帕金森病患者的身體質(zhì)量指數(shù)高于發(fā)病早期對照組,但較晚期對照組水平低,早期帕金森...

【文章頁數(shù)】：40 頁

【學(xué)位級別】：碩士

【文章目錄】：
Abstract
摘要
List of Abbreviations
CHAPTER ONE INTRODUCTION
    1.1 BACKGROUND
    1.2 RELATION BETWEEN NUTRITION,LIFESTYLE,AND PD
    1.3 RELATION BETWEEN OBESITY AND PD
    1.4 GENETICS AND PD
        1.4.1 Monogenic Loci:autosomal dominant mutations
        1.4.2 Autosomal recessive forms
        1.4.3 Recently discovered Gene mutation
    1.5 METABOLIC SYNDROME(METS),OBESITY AND PD
    1.6 ENVIRONMENTAL FACTORS AND PD
    1.7 AUTOIMMUNE DISEASE AND PD
    1.8 The latest consensus on PD management
    1.9 Conclusion
CHAPTER TWO MATERIALS AND METHODS
    2.1 General information and methodology
    2.2 Statistical analysis
CHAPTER THREE RESULTS
    3.1 Patients with PD in early stage,not DDP less than24m,have a BMI higher than
    3.2 BMI of PD patients decreased in the patients of DDP more than 120m
    3.3 Patients with PD in early stage,not DDP less than24m,have a BMI higher than control group
    3.4 The blood lipid level of PD patients decreased with the course of disease
    3.5 Patients with PD in early stage,not DDP less than24m,have a TG higher than control group
    3.6 Waist circumference of PD patients increased slightly in early stage,but decreased with the course of disease
    3.7 BMI in PD is related to DDP and severity of PD
CHAPTER FOUR
    4.1 DISCUSSION
CHAPTER FIVE
    5.1 CONCLUSION
REFERENCES
ACKNOWLEDGEMENT
PUBLICATIONS



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