急性腦梗死患者認(rèn)知功能損傷與病灶及腦結(jié)構(gòu)變化的相關(guān)性及燈盞細(xì)辛注射液干預(yù)的臨床研究
發(fā)布時(shí)間:2022-01-14 04:27
目的1、研究卒中后認(rèn)知障礙與急性期腦梗死病灶、及腦結(jié)構(gòu)的相關(guān)性;2、觀察燈盞細(xì)辛注射液對(duì)急性腦梗死后伴有認(rèn)知功能損害治療后的認(rèn)知功能變化的臨床效果。方法1、采用簡(jiǎn)明精神狀態(tài)檢查表(MMSE)對(duì)納入的149例急性腦梗死患者進(jìn)行評(píng)分,分為認(rèn)知正常組、認(rèn)知障礙組,比較二組梗死灶特點(diǎn)的差異;再將腦卒中的不同部位(單病灶)所測(cè)的MMSE的七個(gè)亞項(xiàng)的結(jié)果進(jìn)行相關(guān)性分析;并從中選取16例伴有明顯認(rèn)知障礙的患者作為觀察組,與12例健康志愿者進(jìn)行腦結(jié)構(gòu)分析,探討卒中后伴有認(rèn)知障礙與腦結(jié)構(gòu)形態(tài)的關(guān)系。2、符合納入標(biāo)準(zhǔn)的60例急性期腦梗死患者,根據(jù)卒中后認(rèn)知功能障礙診斷標(biāo)準(zhǔn),分為兩組:組觀察組(常規(guī)西藥治療+燈盞細(xì)辛注射液),對(duì)照組(常規(guī)西藥治療+依達(dá)拉奉注射液)。療程為2周,治療前后分別進(jìn)行相關(guān)行為學(xué)量表及血液生化檢查。結(jié)果1、與認(rèn)知正常組進(jìn)行對(duì)比,不同梗死灶組MMSE量表總分及各亞項(xiàng)認(rèn)知水平比較,差異均有統(tǒng)計(jì)學(xué)意義(P<0.05);其中丘腦梗死患者定向力、即刻回憶、延時(shí)回憶、計(jì)算力及注意力、視空間損害明顯,基底節(jié)區(qū)梗死患者時(shí)間定向力損害明顯,側(cè)腦室旁梗死患者計(jì)算力及注意力、延時(shí)回憶、語(yǔ)言、視空間損...
【文章來(lái)源】:安徽中醫(yī)藥大學(xué)安徽省
【文章頁(yè)數(shù)】:68 頁(yè)
【學(xué)位級(jí)別】:碩士
【部分圖文】:
梗死灶位置概率圖
圖 2 卒中后伴有認(rèn)知障礙組與正常對(duì)照組灰質(zhì)變化情況[橫狀位,染色區(qū)域?yàn)榛屹|(zhì)減少區(qū)域,簇體積>58 個(gè)體素,P<0.001(FDR 矯正Fig.2 Changes of gray matter in the group with cognitive impairment and the controgroup after stroke[Transverse position, the staining area is the gray matter reduction, areacluster volum58 individual elements, P < 0.001 (FDR correction)]
圖 3 卒中后伴有認(rèn)知障礙組與正常對(duì)照組灰質(zhì)變化情況[冠狀位,染色區(qū)域?yàn)榛屹|(zhì)減少區(qū)域,簇體積>58 個(gè)體素,P<0.001(FDR 矯正)Fig.3 Changes of gray matter in the group with cognitive impairment and the controgroup after stroke[Coronal position, the staining area is the gray matter reduction, areacluster volume 58 individual elements, P < 0.001 (FDR correction)]
本文編號(hào):3587806
【文章來(lái)源】:安徽中醫(yī)藥大學(xué)安徽省
【文章頁(yè)數(shù)】:68 頁(yè)
【學(xué)位級(jí)別】:碩士
【部分圖文】:
梗死灶位置概率圖
圖 2 卒中后伴有認(rèn)知障礙組與正常對(duì)照組灰質(zhì)變化情況[橫狀位,染色區(qū)域?yàn)榛屹|(zhì)減少區(qū)域,簇體積>58 個(gè)體素,P<0.001(FDR 矯正Fig.2 Changes of gray matter in the group with cognitive impairment and the controgroup after stroke[Transverse position, the staining area is the gray matter reduction, areacluster volum58 individual elements, P < 0.001 (FDR correction)]
圖 3 卒中后伴有認(rèn)知障礙組與正常對(duì)照組灰質(zhì)變化情況[冠狀位,染色區(qū)域?yàn)榛屹|(zhì)減少區(qū)域,簇體積>58 個(gè)體素,P<0.001(FDR 矯正)Fig.3 Changes of gray matter in the group with cognitive impairment and the controgroup after stroke[Coronal position, the staining area is the gray matter reduction, areacluster volume 58 individual elements, P < 0.001 (FDR correction)]
本文編號(hào):3587806
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