研究背景高級(jí)別膠質(zhì)瘤是最常見、具有高度增殖和侵襲性的顱內(nèi)腫瘤,具有難治性、易局部播散和易復(fù)發(fā)等特點(diǎn),預(yù)后極差,生存期短,如膠質(zhì)母細(xì)胞瘤,中位生存期14.6-16個(gè)月,5年生存率僅為3.4%。膠質(zhì)瘤的治療需要結(jié)合手術(shù)切除、化療、放療和基于腫瘤的組織學(xué)和分子特征的靶向治療。膠質(zhì)瘤的分子靶向藥物是根據(jù)腦膠質(zhì)瘤發(fā)生及生長(zhǎng)的分子遺傳學(xué)信號(hào)系統(tǒng)所設(shè)計(jì),可以靶向特異靶點(diǎn),阻斷腫瘤的生長(zhǎng),可以明顯提高患者無(wú)瘤生存期。血管內(nèi)皮生長(zhǎng)因子（vascular endothelial growth factor,VEGF）系統(tǒng)是高級(jí)別膠質(zhì)細(xì)胞瘤靶向治療的一個(gè)最有吸引力的靶點(diǎn),高級(jí)別腦膠質(zhì)瘤腫瘤微環(huán)境中特別是低氧、炎癥因子以及炎癥相關(guān)細(xì)胞聚集,使得VEGF表達(dá)量上調(diào),周圍存在高水平VEGF-A,通過(guò)旁分泌機(jī)制促進(jìn)內(nèi)皮細(xì)胞的增殖、存活和遷移。這導(dǎo)致了脈管系統(tǒng)的紊亂與血腦屏障損傷,VEGF過(guò)表達(dá)與血管密度、腫瘤分級(jí)和總體預(yù)后成正比。貝伐單抗具備高親和力且特異性地結(jié)合VEGF-A,是目前神經(jīng)系統(tǒng)高級(jí)別腫瘤最常用的分子靶向藥物,可有效的抑制新生血管生成,對(duì)腫瘤的生長(zhǎng)起到明顯的治療效果。自2009美國(guó)食品和藥物管理局批準(zhǔn)貝... 

【文章來(lái)源】：山東大學(xué)山東省 211工程院校 985工程院校 教育部直屬院校

【文章頁(yè)數(shù)】：80 頁(yè)

【學(xué)位級(jí)別】：博士

【部分圖文】：

膠質(zhì)瘤組織的D2-40,VEGF-G,VEGF-D和VEGFR3染色(200X)

圖２．?Ｄ２－４０和ＶＥＧＦＲ３在高級(jí)別㈧和低級(jí)別（Ｂ）的膠質(zhì)瘤中的表達(dá)差異

圖３．膠質(zhì)瘤組織中Ｄ２－４０，?ＶＥＧＦ－Ｃ，ＶＥＧＦ－Ｄ和ＶＥＧＦＲ－３的表達(dá)。以下是代表性??的圖片：（Ａ）?Ｄ２－４０陽(yáng)性的膠質(zhì)瘤ＩＶ?（＋）。?（Ｂ）?ＶＥＧＦ－Ｃ陽(yáng)性的膠質(zhì)瘤ＩＶ?（＋＋）。??（Ｃ）?ＶＥＧＦ－Ｄ陽(yáng)性的膠質(zhì)瘤ＩＶ?（＋＋）。（Ｄ）?ＶＥＧＦＲ－３陽(yáng)性的膠質(zhì)瘤ＩＶ?（＋）。??

【參考文獻(xiàn)】：
期刊論文
[1]Association of serum vascular endothelial growth factor-C and lymphatic vessel density with lymph node metastasis and prognosis of patients with gastric cancer[J]. Tian-Bao Wang, Mei-hai Deng, Wan-Shou Qiu, Department of General Surgery, the Third Affiliated Hospital, SUN Yat-Sen University, Guangzhou 510630, Guangdong Province, ChinaWen-Guang Dong, Department of Gastrointestinal Surgery, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China.  World Journal of Gastroenterology. 2007(12)
[2]Expression of vascular endothelial growth factor-C and the relationship between lymphangiogenesis and lymphatic metastasis in colorectal cancer[J]. Yi-Tao Jia Wei Liang Department of Oncology,the People’s Hospital of Hebei Province,Shijiazhuang 050051,Hebei Province,China Zhong-Xin Li Yu-Tong He Hui-Chai Yang Department of Surgery,the Forth Hospital of Hebei Medical University,Shijiazhuang 050011,Hebei Province,China Hong-Jun Ma Experimental Centre of Electron Microscopy of Hebei Medical University,Shijiazhuang 050011,Hebei Province,China.  World Journal of Gastroenterology. 2004(22)



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