Detailed mechanisms behind regeneration after nerve injury, in particular signal transduction and the fate of Schwann cells（SCs）, are poorly understood. Here, we investigated axotomy-induced activation of extracellular-signal-regulated kinase-1/2（ERK1/2; important for proliferation） and m-calpain in vitro, and the relation to Ca2+ deletion and Schwann cell proliferation and death after rat sciatic nerve axotomy. Nerve segments were cultured for up to 72 hours with and without ethylene glycol-bis... 

【文章來源】：Neural Regeneration Research. 2017年04期

【文章頁數(shù)】：6 頁

【文章目錄】：
Introduction
Materials and Methods
    Animals
    Organotypic culture of sciatic nerve segments
    Immunohistochemistry
    Photography and image analysis
    Statistical analysis
Results
    p-ERK1/2
    Brd U
    PI
    M-calpain
    Effects of Ca2+deprivation
        p-ERK1/2When the n
        Brd U
        PI
        M-calpain
Discussion



本文編號：2915484