【摘要】：目的探討血漿半乳糖凝集素水平與LAA型腦梗死患者血管病變程度及患者的預(yù)后的關(guān)系。方法按照TOAST分型,選取98例大動脈粥樣硬化型(Large artery atherosclerotic,LAA)腦梗死患者。入院后詳細(xì)詢問病史,記錄患者的性別、年齡、吸煙、飲酒史及既往病史(糖尿病、冠心病史)。行顱腦CT、MRA、TCD,頸部血管超聲、頸部血管CTA、及心臟超聲檢查,排除其它病變,確診為LAA型腦梗死;并將患者按血管的病變支數(shù)分組:單支血管病變、雙支血管病變及多支血管病變組。應(yīng)用酶聯(lián)免疫吸附法(enzyme-linked immunosorbent assay,ELISA)測定所有研究對象血漿半乳糖凝集素-3水平,比較3組患者的血漿半乳糖凝集素-3水平;同時,對患者進(jìn)行3個月的隨訪,給予m RS評分,分為m RS≥3分和m RS3分兩組,結(jié)合受試者工作特征曲線(receiver operating characteristic curve,ROC)評估血漿半乳糖凝集素-3與患者預(yù)后的關(guān)系。結(jié)果各組患者的半乳糖凝集素-3水平比較:多支病變組顯著高于雙支和單支病變組(t=-4.536、-7.298,P=0.000、0.000),雙支病變組顯著高于單支病變組(t=-2.542,P=0.014)。患者的性別、年齡、高血壓病、冠心病、糖尿病、吸煙的影響因素在組間差異無統(tǒng)計學(xué)意義。血糖水平、低密度脂蛋白水平及總膽固醇及半乳糖凝集素-3水平的組間差異有統(tǒng)計學(xué)意義(P0.05)�；颊適 RS評分方面,獨立樣本t檢驗表明分組間差異具有統(tǒng)計學(xué)意義(t=-5.851,P0.000)。Spearman等級相關(guān)證實血漿半乳糖凝集素-3水平與m RS評分成正相關(guān)(r=0.519,P=0.000)�；颊哐獫{gal-3水平與患者預(yù)后的ROC曲線下面積為0.805(95%CI=0.717-0.892,P=0.000)。結(jié)論在LAA型腦梗死患者,血漿半乳糖凝集素-3水平與血管病變支數(shù)呈正相關(guān);往往患者的血管病變支數(shù)越多,患者的動脈粥樣硬化程度就越廣泛。同時患者的血漿半乳糖凝集素-3水平還與患者的m RS評分呈正相關(guān),血漿半乳糖凝集素-3水平越高,患者的m RS評分也越高,預(yù)后越差。提示半乳糖凝集素-3可能參與了缺血性腦卒中患者腦動脈粥樣硬化的炎性發(fā)病機(jī)制,參與了疾病的進(jìn)展過程。本研究提示患者的半乳糖凝集素-3水平有希望成為評價LAA型腦梗死患者的動脈粥樣硬化病變廣泛程度及預(yù)后的血漿標(biāo)志物。
[Abstract]:Objective to investigate the relationship between plasma galactose lectin level and the degree of vascular lesions and prognosis in patients with LAA cerebral infarction. Methods according to TOAST classification, 98 patients with cerebral infarction with atherosclerotic (Large artery atherosclerotic,LAA were selected. Enquire about the medical history after admission and record the patient's sex, age, smoking, drinking history and past history (diabetes, coronary heart disease). Brain CT,MRA,TCD, cervical vascular ultrasound, cervical vascular CTA, and cardiac ultrasound were performed to exclude other lesions and diagnose LAA cerebral infarction, and the patients were divided into three groups according to the number of vessel lesions: single vessel disease, double vessel disease and multi-vessel disease group. Plasma galactose lectin-3 levels were measured by enzyme-linked immunosorbent assay (enzyme-linked immunosorbent assay,ELISA), and plasma galactose lectin-3 levels were compared among the three groups. At the same time, the patients were followed up for 3 months, and the patients were divided into two groups: m RS 鈮，

本文編號：2508662