發(fā)布時(shí)間：2019-06-06 05:43

【摘要】：正P62蛋白(sequestosome 1)是自噬選擇性底物,在形成細(xì)胞質(zhì)蛋白包涵體的過程中起到關(guān)鍵的作用,是阿爾茨海默病(Alzheimer's disease,AD)、帕金森病(Parkinson's disease,PD)和許多慢性退行性疾病的標(biāo)志物[1]。本綜述討論p62蛋白的生理作用及其分子機(jī)制。一、p62蛋白人類的p62蛋白基因位于5號染色體,p62蛋白含有440
[Abstract]:Positive p62 protein (sequestosome 1) is an autophagy selective substrate, which plays a key role in the formation of cytoplasmic protein inclusion bodies. It is Alzheimer's disease (Alzheimer's disease,AD) and Parkinson's disease (Parkinson's disease,). PD) and many markers of chronic degenerative diseases [1]. In this review, the physiological function and molecular mechanism of p62 protein were discussed. One, p62 protein human p62 protein gene is located on chromosome 5, p62 protein contains 440
【作者單位】： 邢臺(tái)市第三醫(yī)院神經(jīng)內(nèi)科;邢臺(tái)市第三醫(yī)院體檢中心;河北醫(yī)科大學(xué)第二醫(yī)院神經(jīng)病學(xué)重點(diǎn)實(shí)驗(yàn)室;
【分類號】：R741
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本文編號：2494111