【摘要】：目的總結(jié)抗N-甲基-D-天冬氨酸受體(NMDAR)腦炎患者的臨床特征。方法收集收治的抗NMDAR腦炎患者的臨床資料,總結(jié)分析其臨床特征、輔助檢查、治療及預(yù)后。根據(jù)有無合并腫瘤將患者分為腫瘤組、無瘤組,對比分析兩組之間的前驅(qū)及首發(fā)癥狀。結(jié)果共納入27例抗NMDAR腦炎患者,男女比例為1∶1.7,發(fā)病年齡9~52歲,中位發(fā)病年齡為24歲。其中腫瘤組9例,均為女性,合并卵巢畸胎瘤;無瘤組18例。腫瘤組和無瘤組在前驅(qū)癥狀、首發(fā)癥狀方面的差異無統(tǒng)計(jì)學(xué)意義(P0.05)。大部分患者經(jīng)免疫治療及腫瘤切除后獲得了較好的預(yù)后。結(jié)論抗NMDAR腦炎發(fā)病率并不低,其與畸胎瘤明顯相關(guān),需要引起神經(jīng)內(nèi)科及婦產(chǎn)科醫(yī)生重視。對于急性起病,出現(xiàn)明顯精神癥狀、癲癇發(fā)作的年輕女性患者,應(yīng)高度警惕抗NMDAR腦炎的可能性,并積極通過影像學(xué)手段篩查腫瘤。
[Abstract]:Objective to summarize the clinical features of patients with anti-N-methyl-D-aspartate receptor (NMDAR). Methods the clinical data of patients with anti-NMDAR meningitis were collected, and their clinical features, auxiliary examination, treatment and prognosis were summarized and analyzed. According to the presence or absence of tumor, the patients were divided into tumor group and tumor-free group, and the prodromes and first symptoms between the two groups were compared and analyzed. Results A total of 27 patients with anti-NMDAR meningitis were enrolled in this study. the ratio of male to female was 1 鈮，

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