【摘要】：目的:研究恒清湯對椎-基底動脈供血不足性(VBI)眩暈的臨床療效及其作用。方法:收集VBI眩暈的門診及住院患者,將其隨機分為治療組(69)及對照組(67)。在基礎治療的基礎下,治療組采用恒清湯治療,對照組采用鹽酸氟桂利嗪膠囊(西比靈)治療,療程4周,共2個療程。治療前后,進行眩暈癥狀評分、歐洲眩暈量表及國際DHI眩暈障礙量表評分,經顱多普勒檢測(TCD)及生化檢查,計算動脈硬化指數(ASI)。結果:治療組總有效率85.51%,對照組總有效率73.13%,兩組比較有統(tǒng)計學差異(P0.05);兩組治療后,與對照組比較,治療組的眩暈癥狀積分明顯降低(P0.01),治療前后差值明顯降低(P0.01),EEV分值及DHI分值均明顯降低(P均0.05),兩側VA和BA的Vp、Vm均升高(P0.05或P0.01),兩側VA和BA的PI和RI均下降(P0.05或P0.01),治療組的TC下降(P0.05),HDL-C升高(P0.05),ASI明顯下降(P0.01),全血高切、全血低切、血漿黏度、RBC聚集指標、纖維蛋白原均下降(P0.05,或P0.01)。結論:恒清湯對VBI眩暈患者有顯著的療效,其機制可能是通過提高VA和BA血流速度,降低總膽固醇、升高高密度脂蛋白,降低ASI,改善血流變指標來實現的。
[Abstract]:Objective: to study the clinical effect and effect of Hengqing decoction on (VBI) vertigo caused by vertebrobasilar insufficiency. Methods: the outpatients and inpatients with VBI vertigo were randomly divided into treatment group (69) and control group (67). On the basis of basic treatment, the treatment group was treated with Hengqing decoction, and the control group was treated with flunarizine hydrochloride capsule (sibelium hydrochloride) for 4 weeks for a total of 2 courses. Before and after treatment, vertigo symptom score, European vertigo scale and international DHI vertigo disorder scale were evaluated, (TCD) and biochemical examination were detected by transcranial Doppler, and (ASI). Of arteriosclerosis index was calculated. Results: the total effective rate of the treatment group was 85.51%, and the total effective rate of the control group was 73.13%, there was statistical difference between the two groups (P0.05). After treatment, the score of vertigo symptom in the treatment group was significantly lower than that in the control group (P0.01), and the difference before and after treatment was significantly lower (P0.01), EEV score and DHI score (both P 0.05). The Vp, of VA and BA on both sides was significantly decreased (P < 0.01). Vm increased (P0.05 or P0.01), PI and RI of both sides of VA and BA decreased (P0.05 or P0.01), TC of treatment group decreased (P0.05), HDL-C increased (P0.05), ASI significantly decreased (P0.01), whole blood cut high, The whole blood low shear rate, plasma viscosity, RBC aggregation index and fibrinogen were all decreased (P 0.05, or P0.01). Conclusion: Hengqing decoction has a significant therapeutic effect on patients with VBI vertigo, its mechanism may be achieved by increasing blood flow velocity of VA and BA, lowering total cholesterol, raising high density lipoprotein (HDL) and lowering ASI, to improve hemorheological indexes.
【作者單位】： 上海交通大學附屬第六人民醫(yī)院;上海市中醫(yī)醫(yī)院;
【基金】：上海市科委中醫(yī)類引導項目(15401933300) 上海市衛(wèi)計委項目(YSNXD-YL-YSZK013)
【分類號】：R743.3

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