【摘要】：背景:研究證實,臍血干細胞可以改善腦卒中后神經(jīng)功能,但臍血干細胞治療腦卒中的機制尚不清楚。目的:綜述臍血干細胞治療腦卒中的效果與機制。方法:由第一作者應用計算機檢索PubMed數(shù)據(jù)庫、中國知網(wǎng)數(shù)據(jù)庫2005年1月至2015年12月的文獻,英文檢索詞為"umbilical cord blood stem cells,stroke",中文檢索詞為"臍血干細胞,腦卒中"。結(jié)果與結(jié)論:隨著人們不斷深入對臍血干細胞神經(jīng)分化的研究,使得臍血干細胞成為神經(jīng)系統(tǒng)疾病治療領域的研究熱點。目前,已有一些腦卒中細胞移植的實驗性治療,取得了理想效果。然而,臍血干細胞治療腦卒中的機制尚不清楚。已知的治療機制包括重組血管、神經(jīng)環(huán)路等損傷組織結(jié)構,分泌各種營養(yǎng)因子,減少內(nèi)源性細胞凋亡,促進內(nèi)源性血管和神經(jīng)再生等。但移植的細胞能否充分填充替代壞死的神經(jīng)細胞促進神經(jīng)功能的恢復;這些存活的干細胞是如何建立神經(jīng)聯(lián)系的;移植細胞是如何減少宿主細胞的凋亡、壞死,恢復受損細胞功能的仍需進一步探索與發(fā)現(xiàn)。
[Abstract]:Background: it has been proved that cord blood stem cells can improve neural function after stroke, but the mechanism of cord blood stem cells in treating stroke is not clear. Objective: to review the effect and mechanism of umbilical cord blood stem cells in the treatment of cerebral apoplexy. Methods: the PubMed database was searched by the first author by computer. The articles from January 2005 to December 2015 were searched with the English and Chinese words of "umbilical cord blood stem cells,stroke" and "Cord blood stem cells, stroke" respectively. Results & conclusion: with the further research on neural differentiation of cord blood stem cells, cord blood stem cells have become a hot spot in the field of treatment of nervous system diseases. At present, there have been some experimental treatment of stroke cell transplantation, and the ideal results have been obtained. However, the mechanism of cord blood stem cells in the treatment of stroke is not clear. Known therapeutic mechanisms include reconstitution of blood vessels, neural loops and other injuried tissue structures, secretion of various nutritional factors, reduction of endogenous cell apoptosis, and promotion of endogenous vascular and neural regeneration. However, whether the transplanted cells can be fully filled with the replacement of necrotic nerve cells to promote the recovery of neural function, and how these surviving stem cells establish neural connections; How to reduce the apoptosis and necrosis of host cells and restore the function of damaged cells still need to be further explored and discovered.
【作者單位】： 內(nèi)蒙古醫(yī)科大學;內(nèi)蒙古醫(yī)科大學第一附屬醫(yī)院神經(jīng)內(nèi)科;
【分類號】：R743.3

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