發(fā)布時間：2019-01-05 06:18

【摘要】：長期暴露于錳會導致產(chǎn)生一些椎體外系的癥狀，與帕金森病（Parkinson’sDisease，PD)的運動癥狀類似。長期慢性錳暴露也會引起一些神經(jīng)行為功能的改變，類似于PD的非運動癥狀。我們從廣西某錳鐵合金冶煉廠中隨機挑選334名分別來自不同崗位的男性工人，將這334名工人分成4個組（對照組、低暴露組、中暴露組、高暴露組），并對其進行兩項問卷調(diào)查：非運動癥狀篩查量表（theNon-MotorSymptomsscale，NMSS)和植物神經(jīng)功能測評量表（SCOPA-AUT）。運用協(xié)方差分析方法對NMSS和SCOPA的得分進行統(tǒng)計分析，以消除教育水平、吸煙、飲酒等混雜因素對結果的影響。結果顯示：從NMSS和SCOPA-AUT的總分來看，，對照組的得分明顯比其他3個暴露組得分低，且有統(tǒng)計學意義（pnmss=0.045,pscopa-aut=0.041）。NMSS和SCOPA-AUT的單項得分結果，各項的對照組得分都比暴露組得分低，而三組暴露組之間得分沒有明顯的規(guī)律，從NMSS的單項得分來看，只有感知障礙的結果統(tǒng)計學意義偏向于臨界點（p=0.05）；從SCOPA-AUT的單項得分來看，只有性功能結果有統(tǒng)計學意義(p=0.015)。故我們認為長期錳暴露損傷了錳暴露工人的神經(jīng)行為功能，特別是性功能等。
[Abstract]:Prolonged exposure to manganese can lead to symptoms of extravertebral systems similar to motor symptoms in Parkinson's disease (Parkinson'sDisease,PD). Long-term chronic manganese exposure also causes changes in neurobehavioral function, similar to the non-motor symptoms of PD. We randomly selected 334 male workers from different positions from a manganese ferroalloy smelter in Guangxi. The 334 workers were divided into four groups (control group, low exposure group, middle exposure group, high exposure group). Two questionnaires were conducted: non-motor symptom screening scale (theNon-MotorSymptomsscale,NMSS) and vegetative nerve function scale (SCOPA-AUT). Covariance analysis was used to analyze the scores of NMSS and SCOPA in order to eliminate the influence of mixed factors such as education level, smoking and drinking. The results showed that the total scores of NMSS and SCOPA-AUT in the control group were significantly lower than those in the other three exposure groups, and there was statistical significance (pnmss=0.045,pscopa-aut=0.041). NMSS and SCOPA-AUT single score results, The scores of the control group were lower than those of the exposure group, but there was no obvious rule between the three exposure groups. From the single score of NMSS, only the results of the perception disorder tended to the critical point statistically (p0. 05). From the single score of SCOPA-AUT, only sexual function results were statistically significant (p0. 015). Therefore, we think that long-term manganese exposure injures the neurobehavioral function, especially sexual function of workers exposed to manganese.
【學位授予單位】：廣西醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R741

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