部分性癲癇合并阻塞性睡眠呼吸暫停低通氣綜合征患者的臨床特征分析
發(fā)布時(shí)間：2018-12-30 10:45
【摘要】：目的:研究部分性癲癇合并阻塞性睡眠呼吸暫停低通氣綜合征(Obstructive sleep apnea syndrome,OSAHS)患者的臨床特征。方法:隨機(jī)選取2015年10月-2016年12月就診于南昌大學(xué)第二附屬醫(yī)院的部分性癲癇患者68例為研究對(duì)象,所有研究對(duì)象均行視頻多導(dǎo)睡眠監(jiān)測(cè)(Polysomnograph,PSG)和同步視頻腦電圖(video-electroencephalogram,VEEG)監(jiān)測(cè),根據(jù)PSG監(jiān)測(cè)結(jié)果判斷有無(wú)OSAHS,將部分性癲癇患者分為癲癇合并OSAHS組(21例)和癲癇未合并OSAHS組(47例),研究部分性癲癇患者的OSAHS的發(fā)生率,通過(guò)比較兩組間的年齡、性別、體重指數(shù)、發(fā)病年齡、病程時(shí)間、夜間發(fā)作、發(fā)作頻率、使用抗癲癇藥種數(shù)、發(fā)作間期癲癇樣放電(interictal epileptiform discharges,IEDs),分析部分性癲癇合并OSAHS患者的臨床特征。實(shí)驗(yàn)結(jié)果使用t檢驗(yàn)、非參數(shù)檢驗(yàn)、卡方檢驗(yàn)及多元逐步線性回歸。結(jié)果:1、68例部分性癲癇患者中達(dá)到OSAHS診斷標(biāo)準(zhǔn)的人數(shù)為21人(30.88%),輕度OSAHS患者13例(61.9%),中度OSAHS患者6例(28.6%),重度OSAHS患者2例(9.5%),其中男15例(71.4%),女6例(28.6%)。2、與癲癇未合并OSAHS組相比,癲癇合并OSAHS組平均血氧飽和度和最低血氧飽和度更低,差異具有統(tǒng)計(jì)學(xué)意義(P0.05)。3、癲癇合并OSAHS組與癲癇未合并OSAHS組相比,年齡、性別、發(fā)病年齡、IEDs差異具有統(tǒng)計(jì)學(xué)意義(P0.05),而體重指數(shù)、病程時(shí)間、夜間發(fā)作、發(fā)作頻率、抗癲癇藥物種數(shù),兩組之間差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。4、發(fā)病年齡和IEDs會(huì)對(duì)AHI產(chǎn)生正向影響,即發(fā)病年齡越大,IEDs陽(yáng)性率越高,AHI也越高。結(jié)論:本研究部分性癲癇合并OSAHS的發(fā)生率為30.88%,主要的臨床特征是中老年男性、發(fā)病年齡較大,IEDs陽(yáng)性率更高。
[Abstract]:Objective: to study the clinical features of partial epilepsy with obstructive sleep apnea hypopnea syndrome (Obstructive sleep apnea syndrome,OSAHS). Methods: Sixty-eight patients with partial epilepsy who were admitted to Nanchang University second affiliated Hospital from October 2015 to December 2016 were randomly selected as subjects. All subjects were monitored by video polysomnography (Polysomnograph,). PSG) and synchronous video EEG (video-electroencephalogram,VEEG) monitoring. According to the results of PSG monitoring, the patients with partial epilepsy were divided into two groups: OSAHS group (21 cases) and non-epileptic OSAHS group (47 cases). To study the incidence of OSAHS in patients with partial epilepsy, we compared the age, sex, body mass index, onset age, duration of disease, nocturnal attack, frequency of seizure, number of antiepileptic drugs used between the two groups. Interictal epileptiform discharge (interictal epileptiform discharges,IEDs) was used to analyze the clinical features of partial epilepsy with OSAHS. T test, non-parametric test, chi-square test and multivariate stepwise linear regression were used. Results: (1) among 68 patients with partial epilepsy, 21 (30.88%) met the diagnostic criteria of OSAHS, 13 (61.9%) mild OSAHS, 6 (28.6%) moderate OSAHS, and 2 (9.5%) severe OSAHS. There were 15 males (71.4%) and 6 females (28.6%). Compared with the patients with epilepsy without OSAHS, the mean oxygen saturation and the lowest oxygen saturation were lower in the epilepsy with OSAHS group (P0.05). There were significant differences in age, sex, onset age and IEDs between OSAHS group and non-epileptic OSAHS group (P0.05), while body mass index, duration of disease, nocturnal attack, frequency of seizure, number of antiepileptic drugs were significant (P0.05). There was no significant difference between the two groups (P0.05). 4, onset age and IEDs will have a positive effect on AHI, that is, the older the age of onset, the higher the positive rate of IEDs and the higher the AHI. Conclusion: the incidence of partial epilepsy with OSAHS in this study is 30.88. The main clinical characteristics of this study are middle-aged and elderly men with older onset age and higher IEDs positive rate.
【學(xué)位授予單位】：南昌大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R766;R742.1
本文編號(hào)：2395475
[Abstract]:Objective: to study the clinical features of partial epilepsy with obstructive sleep apnea hypopnea syndrome (Obstructive sleep apnea syndrome,OSAHS). Methods: Sixty-eight patients with partial epilepsy who were admitted to Nanchang University second affiliated Hospital from October 2015 to December 2016 were randomly selected as subjects. All subjects were monitored by video polysomnography (Polysomnograph,). PSG) and synchronous video EEG (video-electroencephalogram,VEEG) monitoring. According to the results of PSG monitoring, the patients with partial epilepsy were divided into two groups: OSAHS group (21 cases) and non-epileptic OSAHS group (47 cases). To study the incidence of OSAHS in patients with partial epilepsy, we compared the age, sex, body mass index, onset age, duration of disease, nocturnal attack, frequency of seizure, number of antiepileptic drugs used between the two groups. Interictal epileptiform discharge (interictal epileptiform discharges,IEDs) was used to analyze the clinical features of partial epilepsy with OSAHS. T test, non-parametric test, chi-square test and multivariate stepwise linear regression were used. Results: (1) among 68 patients with partial epilepsy, 21 (30.88%) met the diagnostic criteria of OSAHS, 13 (61.9%) mild OSAHS, 6 (28.6%) moderate OSAHS, and 2 (9.5%) severe OSAHS. There were 15 males (71.4%) and 6 females (28.6%). Compared with the patients with epilepsy without OSAHS, the mean oxygen saturation and the lowest oxygen saturation were lower in the epilepsy with OSAHS group (P0.05). There were significant differences in age, sex, onset age and IEDs between OSAHS group and non-epileptic OSAHS group (P0.05), while body mass index, duration of disease, nocturnal attack, frequency of seizure, number of antiepileptic drugs were significant (P0.05). There was no significant difference between the two groups (P0.05). 4, onset age and IEDs will have a positive effect on AHI, that is, the older the age of onset, the higher the positive rate of IEDs and the higher the AHI. Conclusion: the incidence of partial epilepsy with OSAHS in this study is 30.88. The main clinical characteristics of this study are middle-aged and elderly men with older onset age and higher IEDs positive rate.
【學(xué)位授予單位】：南昌大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R766;R742.1
【參考文獻(xiàn)】
相關(guān)期刊論文 前1條
1 呂向裴;張成;馬靖;宿利;賈鵬;羅義萍;魏淑敏;王廣發(fā);;柏林問卷在阻塞性睡眠呼吸暫停低通氣綜合征篩查中的應(yīng)用價(jià)值[J];中華結(jié)核和呼吸雜志;2011年07期
，本文編號(hào)：2395475
本文鏈接：http://sikaile.net/yixuelunwen/shenjingyixue/2395475.html
最近更新
教材專著
