腦動脈支架術后不同抗血小板方案對比研究
發(fā)布時間：2018-12-13 19:28
【摘要】：目的:評價雙聯(lián)抗血小板藥物時間及單一抗血小板藥物種類對腦動脈支架術后患者的療效和不良反應。方法:本實驗為回顧性調(diào)查研究,共納入380例病例,根據(jù)術后聯(lián)合使用阿司匹林和氯吡格雷時間長短分為3組:A組(60例)聯(lián)用1個月,B組(220例)聯(lián)用3個月,C組(100例)聯(lián)用4~12個月;根據(jù)A、B組病例停用雙抗后使用單一抗血小板藥物種類不同分為2個亞組:AB1組(132例)服用阿司匹林,AB2組(91例)服用氯吡格雷。通過卡方檢驗或Fisher精確檢驗及多因素logistic回歸分析比較術后1年內(nèi)再發(fā)腦梗死、腦出血、顱外出血、心肌梗死、死亡等不良事件發(fā)生率。結果:術后1年內(nèi),A、B、C 3組間再發(fā)腦梗死無明顯差異(P=0.580);AB組亞組間腦梗死再發(fā)率也無統(tǒng)計學差異(P=1.000);A、B、C 3組間及AB組亞組間腦出血、顱外出血、心肌梗死、死亡發(fā)生率無統(tǒng)計學差別(P0.05)。結論:阿司匹林和氯吡格雷聯(lián)用1個月、3個月、4~12個月以及停用雙抗后單用阿司匹林或氯吡格雷具有同等療效。
[Abstract]:Aim: to evaluate the efficacy and adverse reactions of dual antiplatelet drugs and single antiplatelet drugs in patients after cerebral artery stenting. Methods: a retrospective study was conducted in 380 patients who were divided into three groups according to the duration of combined use of aspirin and clopidogrel: group A (60 cases) and group B (220 cases) for 3 months. Group C (100 cases) were treated for 4 ~ 12 months; Patients in group A were divided into two subgroups: AB1 group (n = 132) taking aspirin and AB2 group (n = 91) taking clopidogrel. The incidence of recurrent cerebral infarction, intracerebral hemorrhage, extracranial hemorrhage, myocardial infarction and death were compared by chi-square test, Fisher accurate test and multivariate logistic regression analysis. Results: within 1 year after operation, there was no significant difference in the recurrence rate of diencephalic infarction between the two groups (P < 0. 580); AB). There was no significant difference in diencephalic hemorrhage, extracranial hemorrhage, myocardial infarction and death rate between the two groups (P0.05). Conclusion: aspirin combined with clopidogrel for 1 month, 3 months, 4 ~ 12 months, or clopidogrel alone has the same effect.
【作者單位】： 重慶醫(yī)科大學第一附屬醫(yī)院神經(jīng)內(nèi)科;第三軍醫(yī)大學新橋醫(yī)院神經(jīng)內(nèi)科;
【基金】：重慶市醫(yī)學科研計劃資助項目(編號:2012-2-511)
【分類號】：R743.3
本文編號：2377088
[Abstract]:Aim: to evaluate the efficacy and adverse reactions of dual antiplatelet drugs and single antiplatelet drugs in patients after cerebral artery stenting. Methods: a retrospective study was conducted in 380 patients who were divided into three groups according to the duration of combined use of aspirin and clopidogrel: group A (60 cases) and group B (220 cases) for 3 months. Group C (100 cases) were treated for 4 ~ 12 months; Patients in group A were divided into two subgroups: AB1 group (n = 132) taking aspirin and AB2 group (n = 91) taking clopidogrel. The incidence of recurrent cerebral infarction, intracerebral hemorrhage, extracranial hemorrhage, myocardial infarction and death were compared by chi-square test, Fisher accurate test and multivariate logistic regression analysis. Results: within 1 year after operation, there was no significant difference in the recurrence rate of diencephalic infarction between the two groups (P < 0. 580); AB). There was no significant difference in diencephalic hemorrhage, extracranial hemorrhage, myocardial infarction and death rate between the two groups (P0.05). Conclusion: aspirin combined with clopidogrel for 1 month, 3 months, 4 ~ 12 months, or clopidogrel alone has the same effect.
【作者單位】： 重慶醫(yī)科大學第一附屬醫(yī)院神經(jīng)內(nèi)科;第三軍醫(yī)大學新橋醫(yī)院神經(jīng)內(nèi)科;
【基金】：重慶市醫(yī)學科研計劃資助項目(編號:2012-2-511)
【分類號】：R743.3
【相似文獻】
相關期刊論文 前3條
1 張華;畢齊;;腦卒中患者經(jīng)皮冠狀動脈成形術加支架術后再發(fā)急性腦血管病分析[J];心肺血管病雜志;2009年04期
2 趙文元,劉建民,許奕,洪波,黃清海,張瓏,周曉平;支架輔助GDC治療顱內(nèi)動脈瘤術中并發(fā)癥的防治[J];介入放射學雜志;2003年03期
3 魏丹;謝先龍;王細林;;血管成形及支架術治療椎動脈起始部狹窄13例臨床觀察[J];神經(jīng)損傷與功能重建;2013年04期
相關博士學位論文 前1條
1 陳永安;支架在血管內(nèi)治療顱內(nèi)動脈瘤中的應用[D];山東大學;2014年
，本文編號：2377088
本文鏈接：http://sikaile.net/yixuelunwen/shenjingyixue/2377088.html
最近更新
教材專著
