【摘要】：海馬CA3和內(nèi)嗅皮層(entorhinal cortex,EC)網(wǎng)絡(luò)是海馬認(rèn)知功能和顳葉癲癇研究的關(guān)鍵回路之一,尖波對(duì)海馬網(wǎng)絡(luò)theta(4~8 Hz)節(jié)律抑制作用的研究有利于揭示癲癇對(duì)認(rèn)知功能影響的機(jī)制。以往,在網(wǎng)絡(luò)層面上,該抑制作用常借助腦片來實(shí)現(xiàn)定量評(píng)估。本文旨在建立依賴于腦深度局部場(chǎng)電位評(píng)估癲癇尖波對(duì)theta節(jié)律抑制作用的方法。從4位術(shù)前處于快速眼球運(yùn)動(dòng)(rapid eyes movement,REM)睡眠下的顳葉癲癇患者皮質(zhì)電極記錄中擇取發(fā)作間期有散發(fā)性尖波(sporadic spikes,SSs)腦電和兩個(gè)相鄰SSs間無尖波暫態(tài)期腦電,尖波分別只在CA3、只在EC、或在CA3和EC同步出現(xiàn),應(yīng)用Gabor小波和Hilbert變換計(jì)算尖波前后和無尖波暫態(tài)期theta能量,并計(jì)算無尖波暫態(tài)期theta節(jié)律的斷裂程度。結(jié)果顯示:(1)尖波可瞬時(shí)降低theta能量,CA3和EC同步尖波時(shí)下降最為劇烈,抑制作用最強(qiáng);(2)無尖波暫態(tài)期theta能量下降,出現(xiàn)theta節(jié)律消失,造成節(jié)律斷裂,表明抑制作用在持續(xù),且斷裂程度與尖波附近抑制作用一致;(3)3例患者無尖波暫態(tài)期theta能量水平降低程度與尖波附近抑制作用一致,而1例不一致。本文結(jié)果提示,SSs可對(duì)theta節(jié)律產(chǎn)生瞬時(shí)、直接的抑制作用,該抑制作用可在無尖波暫態(tài)期持續(xù),并可由theta節(jié)律斷裂程度反映。該工作首次應(yīng)用局部場(chǎng)電位證明了癲癇尖波對(duì)theta節(jié)律抑制作用可通過無尖波時(shí)腦電節(jié)律的斷裂程度來評(píng)估,為利用腦電衡量癲癇尖波抑制作用提供了量化分析方法。
[Abstract]:Hippocampal CA3 and entorhinal cortex (entorhinal cortex,EC) network are one of the key circuits in the study of hippocampal cognitive function and temporal lobe epilepsy. The study of the inhibitory effect of sharp waves on the rhythm of hippocampal network theta (48 Hz) is helpful to reveal the mechanism of the effect of epilepsy on cognitive function. In the past, at the network level, the inhibitory effect was often evaluated quantitatively by brain slices. The purpose of this paper is to establish a method to evaluate the inhibitory effect of epileptic cusp on theta rhythm depending on the depth of brain field potential. In 4 patients with temporal lobe epilepsy who were in the condition of rapid eye movement (rapid eyes movement,REM) sleep before operation, the interictal sporadic sharp wave (sporadic spikes,SSs) EEG and the non-sharp wave transient EEG between the two adjacent SSs were selected from the cortical electrode records. The sharp waves appear only in EC, at CA3, or in CA3 and EC at the same time. Using Gabor wavelet and Hilbert transform to calculate the theta energy before and after the sharp wave and the transient phase without the sharp wave, and to calculate the breaking degree of the theta rhythm in the non-sharp wave transient phase. The results showed that: (1) the energy of theta could be instantly decreased by the sharp wave, and the decrease of CA3 and EC was the most severe, and the inhibitory effect was the strongest at the time of synchronous sharp wave of CA3 and EC; (2) the theta energy decreases and the theta rhythm disappears during the non-sharp wave transient period, which results in the rhythm breaking, indicating that the inhibition action is continuing, and the degree of the fracture is consistent with that near the sharp wave. (3) the decrease of theta energy level in 3 patients without sharp wave transient phase was consistent with the inhibitory effect near the sharp wave, but not in 1 case. The results suggest that SSs can produce transient and direct inhibitory effect on theta rhythm, which can be sustained during the non-sharp wave transient period, and can be reflected by the breaking degree of theta rhythm. For the first time, the local field potential has proved that the inhibitory effect of epileptic sharp waves on theta rhythm can be evaluated by the breaking degree of EEG rhythm without sharp waves, which provides a quantitative analysis method for the use of EEG to measure the inhibitory effect of epileptic sharp waves.
【作者單位】： 河北工業(yè)大學(xué)電磁場(chǎng)與磁性材料省部共建國(guó)家重點(diǎn)實(shí)驗(yàn)室電氣工程學(xué)院;
【分類號(hào)】：Q4

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