【摘要】：目的探討與非溶栓性缺血性卒中患者出血性轉(zhuǎn)化相關(guān)的危險(xiǎn)因素。方法回顧性分析2014年1月-2016年12月我院收治的非溶栓性缺血性卒中患者共計(jì)426例,收集其基本信息、臨床指標(biāo)和影像學(xué)的資料,采用多元Logistic回歸模型分析非溶栓性缺血性卒中出血性轉(zhuǎn)化相關(guān)的危險(xiǎn)因素。結(jié)果在我們納入的病例中出血性轉(zhuǎn)化(hemorrhagic transformation,HT)的發(fā)生率為17.3%。多元Logistic回歸分析表明,高血壓病(OR 0.463,95%CI 0.276~0.774)、房顫(OR 3.814,95%CI 1.870~7.775)、大面積腦梗死(OR 2.883,95%CI 1.506~5.520)及腎小球?yàn)V過(guò)率(estimated glomerular filtration rate,eGFR)60mL/min/1.73 m2(OR1.993,95%CI 0.994~3.995)是發(fā)生出血性轉(zhuǎn)化的獨(dú)立危險(xiǎn)因素(P0.05)。結(jié)論高血壓病、房顫、大面積腦梗死及eGFR60mL/min/1.73 m2是非溶栓性缺血性卒中出血性轉(zhuǎn)化的獨(dú)立危險(xiǎn)因素;與既往研究相比,我們的研究資料提示檢測(cè)eGFR指標(biāo)對(duì)預(yù)測(cè)非溶栓性缺血性卒中出血性轉(zhuǎn)化有一定潛在價(jià)值。
[Abstract]:Objective to investigate the risk factors associated with hemorrhagic transformation in patients with non-thrombolytic ischemic stroke. Methods 426 patients with non-thrombolytic ischemic stroke from January 2014 to December 2016 were retrospectively analyzed and their basic information, clinical indexes and imaging data were collected. Multivariate Logistic regression model was used to analyze the risk factors associated with hemorrhagic transformation in non-thrombolytic ischemic stroke. Results the incidence of hemorrhagic transformation (hemorrhagic transformation,HT) in our patients was 17. 3%. Multivariate Logistic regression analysis showed that hypertension (OR 0.46395 CI 0.276c0.774), atrial fibrillation (OR 3.81495 CI 1.8707.775), massive cerebral infarction (OR 2.88395 CI 1.5065.520) and glomerular filtration rate (estimated glomerular filtration rate,) EGFR) 60mL/min/1.73 m2 (OR1.993,95%CI 0.994 + 3.995) was an independent risk factor for hemorrhagic transformation (P0.05). Conclusion Hypertension, atrial fibrillation, large area cerebral infarction and eGFR60mL/min/1.73 m2 are independent risk factors for hemorrhagic transformation of non-thrombolytic ischemic stroke. Compared with previous studies, our data suggest that the detection of eGFR is of potential value in the prediction of hemorrhagic transformation in non-thrombolytic ischemic stroke.
【學(xué)位授予單位】：重慶醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：R743.3

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