重癥肌無力患者血清Titin和RyR抗體的臨床研究
發(fā)布時間：2018-10-23 20:44
【摘要】：目的：探討血清Titin抗體和Ryanodine受體(RyR)抗體在重癥肌無力(myasthenia gravis,MG),尤其是合并胸腺瘤MG(MGT)和晚發(fā)型MG診斷中的臨床意義。 方法：采用酶聯(lián)免疫吸附試驗(ELISA),檢測61例MG患者(胸腺瘤24例,胸腺增生6例,胸腺正常31例)和35例正常對照組患者(NC)的血清Titin抗體和RyR抗體。 結(jié)果：①MG組Titin抗體和RyR抗體陽性率分別為62.3%和49.2%,對照組兩種抗體陽性率分別為11.4%和8.6%,MG組兩種抗體陽性率均顯著高于對照組,差異均有統(tǒng)計學(xué)意義(P0.05)；②合并胸腺瘤MG組患者Titin抗體陽性率(為83.3%)明顯高于未合并胸腺瘤MG組陽性率(為48.6%),差異均有統(tǒng)計學(xué)意義(P0.05)；合并胸腺瘤MG組和未合并胸腺瘤MG組患者RyR抗體陽性率(分別為58.3%、43.2%)差異無統(tǒng)計學(xué)意義(P0.05)；③晚發(fā)型MG患者中Titin抗體和RyR抗體均有較高的陽性率(分別為80.0%和63.3%),明顯高于早發(fā)型MG患者的陽性率(分別為45.2%和35.5%),差異均有統(tǒng)計學(xué)意義(P0.05)；④MG患者Titin抗體和RyR抗體水平與肌無力嚴(yán)重程度相關(guān)分析呈正相關(guān)(r分別為0.520和0.487,P0.001)。 結(jié)論：Titin抗體和RyR抗體檢測有助于MG的診斷。在晚發(fā)型MG患者,Titin抗體和RyR抗體有較高陽性率。在合并胸腺瘤MG患者中,Titin抗體也有較高陽性率。Titin抗體和RyR抗體水平與MG患者肌無力嚴(yán)重程度呈正相關(guān),對評價病情與預(yù)后均有幫助。
[Abstract]:Objective: to investigate the clinical significance of serum Titin antibody and Ryanodine receptor (RyR) antibody in the diagnosis of myasthenia gravis (myasthenia gravis,MG), especially with thymoma MG (MGT) and late-onset MG. Methods: the serum Titin and RyR antibodies of 61 patients with MG (24 thymoma, 6 thymic hyperplasia, 31 normal thymus) and 35 normal controls were detected by enzyme linked immunosorbent assay (ELISA),). Results: the positive rates of Titin antibody and RyR antibody in 1MG group were 62.3% and 49.2%, respectively. The positive rates of Titin antibody and RyR antibody in control group were 11.4% and 8.6%, respectively, which were significantly higher than those in control group (P0.05). 2the positive rate of Titin antibody in MG group with thymoma (83.3%) was significantly higher than that in MG group without thymoma (48.6%), the difference was statistically significant (P0.05). The positive rate of RyR antibody in patients with thymoma MG and MG without thymoma was 58.3% and 43.2%, respectively. There was no significant difference between the two groups (P0.05). The positive rates of Titin antibody and RyR antibody were 80.0% and 63.3% in patients with late-onset MG (80.0% and 63.3%, respectively), which were significantly higher than those in patients with early-onset MG (45.2% and 35.5%, respectively), the difference was statistically significant (P0.05). The levels of Titin antibody and RyR antibody were positively correlated with the severity of myasthenia in patients with 4MG (r = 0.520 and 0.487g P0.001, respectively). Conclusion: the detection of Titin antibody and RyR antibody is helpful for the diagnosis of MG. The positive rates of Titin antibody and RyR antibody were higher in late onset MG patients. In patients with thymoma MG, the positive rate of Titin antibody was also high. The levels of Titin antibody and RyR antibody were positively correlated with the severity of myasthenia in MG patients, which was helpful to evaluate the severity and prognosis of MG.
【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R746.1
本文編號：2290414
[Abstract]:Objective: to investigate the clinical significance of serum Titin antibody and Ryanodine receptor (RyR) antibody in the diagnosis of myasthenia gravis (myasthenia gravis,MG), especially with thymoma MG (MGT) and late-onset MG. Methods: the serum Titin and RyR antibodies of 61 patients with MG (24 thymoma, 6 thymic hyperplasia, 31 normal thymus) and 35 normal controls were detected by enzyme linked immunosorbent assay (ELISA),). Results: the positive rates of Titin antibody and RyR antibody in 1MG group were 62.3% and 49.2%, respectively. The positive rates of Titin antibody and RyR antibody in control group were 11.4% and 8.6%, respectively, which were significantly higher than those in control group (P0.05). 2the positive rate of Titin antibody in MG group with thymoma (83.3%) was significantly higher than that in MG group without thymoma (48.6%), the difference was statistically significant (P0.05). The positive rate of RyR antibody in patients with thymoma MG and MG without thymoma was 58.3% and 43.2%, respectively. There was no significant difference between the two groups (P0.05). The positive rates of Titin antibody and RyR antibody were 80.0% and 63.3% in patients with late-onset MG (80.0% and 63.3%, respectively), which were significantly higher than those in patients with early-onset MG (45.2% and 35.5%, respectively), the difference was statistically significant (P0.05). The levels of Titin antibody and RyR antibody were positively correlated with the severity of myasthenia in patients with 4MG (r = 0.520 and 0.487g P0.001, respectively). Conclusion: the detection of Titin antibody and RyR antibody is helpful for the diagnosis of MG. The positive rates of Titin antibody and RyR antibody were higher in late onset MG patients. In patients with thymoma MG, the positive rate of Titin antibody was also high. The levels of Titin antibody and RyR antibody were positively correlated with the severity of myasthenia in MG patients, which was helpful to evaluate the severity and prognosis of MG.
【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R746.1
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