基于血管再通的神經(jīng)保護(hù)治療臨床研究進(jìn)展
發(fā)布時(shí)間:2018-09-11 07:32
【摘要】:正急性缺血性卒中(acute ischemic stroke,AIS)為血管閉塞后腦組織供血障礙而發(fā)生缺血壞死所導(dǎo)致的一大類疾病。1995年至2015年,靜脈溶栓是唯一被證實(shí)有效的AIS血管再通治療措施,但靜脈溶栓存在治療時(shí)間窗短、禁忌證多、出血風(fēng)險(xiǎn)大、對大動(dòng)脈閉塞的開通效果差等缺點(diǎn)。2015年以來,隨著"五大試驗(yàn)"(即MR CLEAN、EXTEND IA、ESCAPE、SWIFT PRIME及REVASCAT)結(jié)果的公布,血管內(nèi)治療對AIS的治療效果首次得到肯定,能顯著提高
[Abstract]:Acute ischemic stroke (acute ischemic stroke,AIS) is a major type of disease caused by ischemic necrosis due to impaired cerebral blood supply after vascular occlusion. From 1995 to 2015, intravenous thrombolysis was the only proven effective therapy for the recanalization of AIS blood vessels. However, intravenous thrombolysis has some disadvantages, such as short time window, multiple contraindications, high risk of bleeding, and poor opening effect of large artery occlusion. Since 2015, with the publication of the results of the "five major trials" (MR CLEAN,EXTEND IA,ESCAPE,SWIFT PRIME and REVASCAT), The effect of endovascular therapy on AIS is confirmed for the first time and can be improved significantly.
【作者單位】: 首都醫(yī)科大學(xué)宣武醫(yī)院神經(jīng)內(nèi)科;首都醫(yī)科大學(xué)宣武醫(yī)院神經(jīng)外科;
【基金】:國家杰出青年科學(xué)基金(81325007)
【分類號】:R743.3
本文編號:2236028
[Abstract]:Acute ischemic stroke (acute ischemic stroke,AIS) is a major type of disease caused by ischemic necrosis due to impaired cerebral blood supply after vascular occlusion. From 1995 to 2015, intravenous thrombolysis was the only proven effective therapy for the recanalization of AIS blood vessels. However, intravenous thrombolysis has some disadvantages, such as short time window, multiple contraindications, high risk of bleeding, and poor opening effect of large artery occlusion. Since 2015, with the publication of the results of the "five major trials" (MR CLEAN,EXTEND IA,ESCAPE,SWIFT PRIME and REVASCAT), The effect of endovascular therapy on AIS is confirmed for the first time and can be improved significantly.
【作者單位】: 首都醫(yī)科大學(xué)宣武醫(yī)院神經(jīng)內(nèi)科;首都醫(yī)科大學(xué)宣武醫(yī)院神經(jīng)外科;
【基金】:國家杰出青年科學(xué)基金(81325007)
【分類號】:R743.3
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