【摘要】：正1890年,Neumann~([1])首次在多發(fā)性腦硬化患者的腦硬化斑塊邊緣發(fā)現(xiàn)肥大細胞(Mast cells,MCs)~([2])。大量實驗表明腦部MCs分泌或活化釋放的物質(zhì)參與腦內(nèi)炎癥反應(yīng)以及神經(jīng)系統(tǒng)炎癥的病理過程,如自閉癥譜系障礙、多發(fā)性腦硬化和阿爾茲海默癥~([3,4])。自閉癥譜系障礙(Autism spectrum disorder,ASD)是一種和神經(jīng)炎癥有關(guān)的神經(jīng)發(fā)展性障礙,患者的交流和行為存在缺陷。根據(jù)2012年美國
[Abstract]:In 1890, Neumann ~ (1) was the first to find mast cells (Mast cells,MCs) on the edge of multiple brain sclerosis (MS) plaques. A large number of experiments have shown that the MCs secreted or activated by the brain is involved in the pathological processes of inflammation in the brain and inflammation of the nervous system, such as autism spectrum disorders, multiple brain sclerosis and Alzheimer's disease. Autism spectrum disorder (Autism spectrum disorder,ASD) is a neurodevelopmental disorder associated with neuroinflammation. According to the United States in 2012,
【作者單位】： 常州大學(xué)制藥與生命科學(xué)學(xué)院;
【基金】：常州大學(xué)人才引進基金(ZMF14020066) 常州科技局國際交流研究基金(KYJ1520305)資助
【分類號】：R741
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本文編號：2230913