【摘要】：異檸檬酸脫氫酶(isocitrate dehvdrogenase,IDH)是三羧酸循環(huán)的關(guān)鍵酶,催化異檸檬酸氧化脫羧生成α-酮戌二酸(α-ketoglutaric acid,α-KG),同時(shí)利用煙酰胺腺嘌呤二核苷酸(nicotinamide adeninedinudeotide,NAD~+)/煙酰胺腺嘌呤二核苷磷酸(nicotinamide adenine dinucleotide phosphate,NADP~+)作為輔助因子生成還原型NADH/NADPH。超過75%的低級別膠質(zhì)瘤(WHO分級為Ⅱ和Ⅲ級)和90%的繼發(fā)性成膠質(zhì)細(xì)胞瘤中存在IDH基因突變,且主要突變位點(diǎn)為R132H(132位精氨酸突變?yōu)榻M氨酸)。IDH基因突變改變了膠質(zhì)瘤的表觀遺傳學(xué)特征,使膠質(zhì)瘤代謝重編程,破壞膠質(zhì)瘤氧化還原穩(wěn)態(tài)。以突變的IDH基因?yàn)橹委煱悬c(diǎn)能抑制膠質(zhì)瘤的進(jìn)展,可用于新的抗腫瘤藥物的研發(fā)。
[Abstract]:Isocitrate dehydrogenase (isocitrate dehvdrogenase idh) is a key enzyme in the tricarboxylic acid cycle. 偽 -ketoglutaric acid (偽 -KG) was synthesized by catalytic oxidation of isocitric acid to 偽 -ketoglutaric acid (偽 -KG). At the same time, nicotinamide adenine dinucleotide (NAD ~) / nicotinamide adenine dinucleotide phosphate (nicotinamide adenine dinucleotide) was used as an auxiliary factor to produce reduced NADH / NADPH. More than 75% of low-grade gliomas (WHO grade 鈪，

本文編號：2198589