【摘要】：目的探討微創(chuàng)顱內(nèi)血腫清除對(duì)降低病灶周圍腦組織谷氨酸(Glu)水平、血腦屏障(BBB)通透性及腦水腫的影響。方法將30只體質(zhì)量2.80~3.40kg的家兔制作自發(fā)性腦出血(ICH)模型,模型制作成功后,分成對(duì)照組(MC組)和微創(chuàng)組(MI組),MI組于造模后6h內(nèi)通過(guò)立體定向儀行微創(chuàng)顱內(nèi)血腫清除術(shù),于術(shù)后1、3、7d提取腦組織,檢測(cè)血腫周圍腦組織Glu水平、BBB通透性及腦含水量,并與對(duì)照組進(jìn)行比較分析。結(jié)果 MI組在術(shù)后1、3、7d血腫周圍腦組織Glu水平、BBB通透性及腦含水量均低于MC組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論微創(chuàng)技術(shù)清除顱內(nèi)血腫有利于降低血腫周圍Glu水平、BBB透性及腦含水量。
[Abstract]:Objective to investigate the effects of minimally invasive removal of intracranial hematoma on the level of glutamate (Glu), the permeability of blood-brain barrier (BBB) and brain edema in perifocal brain tissue. Methods the (ICH) model of spontaneous intracerebral hemorrhage was made in 30 rabbits with body mass 2.80~3.40kg. After the establishment of the model, the model was divided into two groups: the control group (MC group) and the minimally invasive group (MI group). The minimally invasive intracerebral hematoma clearance was performed by stereotactic instrument within 6 hours after the establishment of the model in the control group (MC group) and the minimally invasive group (MI group). Brain tissue was extracted at 1: 3 and 7 days after operation. The permeability and water content of Glu in brain tissue around hematoma were measured and compared with those in control group. Results the level of Glu in the brain tissue around hematoma in MI group was significantly lower than that in MC group on the 1st and 7th day after operation (P0.05). Conclusion minimally invasive removal of intracranial hematoma is beneficial to reduce the permeability and water content of Glu around the hematoma.
【作者單位】： 貴州省貴陽(yáng)市第二人民醫(yī)院神經(jīng)內(nèi)科;貴州醫(yī)科大學(xué)計(jì)算機(jī)教研室;貴州醫(yī)科大學(xué)神經(jīng)病學(xué)教研室;
【基金】：貴陽(yáng)市衛(wèi)生和計(jì)劃生育委員會(huì)科學(xué)技術(shù)計(jì)劃項(xiàng)目[(2015)筑衛(wèi)計(jì)科技合同字第074號(hào)] 貴州省高血壓性顱內(nèi)出血微創(chuàng)診療科技創(chuàng)新人才團(tuán)隊(duì)
【分類號(hào)】：R743.34

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