發(fā)布時(shí)間：2018-08-13 11:19

【摘要】：目的探討嚴(yán)重腦白質(zhì)疏松癥的相關(guān)因素。方法按照篩選標(biāo)準(zhǔn)連續(xù)收集2015年4月-2016年2月武漢大學(xué)中南醫(yī)院神經(jīng)內(nèi)科住院患者,通過(guò)頭部核磁共振評(píng)估腦白質(zhì)疏松癥Fazekas評(píng)分并收集相關(guān)臨床資料,并應(yīng)用非條件Logistic回歸來(lái)分析嚴(yán)重腦白質(zhì)疏松癥的相關(guān)因素。結(jié)果共納入608例患者,包括Fazekas評(píng)分為0的對(duì)照組415例和Fazekas評(píng)分為3~6的病例組193例。多因素Logistic回歸結(jié)果提示:高齡(G3 vs G1:OR10.81,95%CI 2.76~42.38,P=0.001;G4 vs G1:OR 28.40,95%CI 7.02~114.95,P0.05;G5 vs G1:OR 68.79,95%CI 14.22~332.92,P0.05)、腦動(dòng)脈粥樣硬化(OR 1.98,95%CI 1.07~3.65,P=0.029)和高血壓病(OR=4.84,95%CI=2.65~8.85,P0.05)與嚴(yán)重腦白質(zhì)疏松癥之間呈顯著正相關(guān)。結(jié)論高齡、腦動(dòng)脈粥樣硬化和高血壓病可能是嚴(yán)重腦白質(zhì)疏松癥的獨(dú)立危險(xiǎn)因素。
[Abstract]:Objective to investigate the related factors of severe leukoaraiosis. Methods according to the screening criteria, the inpatients in the Department of Neurology, Central South Hospital, Wuhan University from April 2015 to February 2016 were collected. The Fazekas score of leukoaraiosis was evaluated by head MRI and the relevant clinical data were collected. Non-conditional Logistic regression was used to analyze the related factors of severe leukoaraiosis. Results A total of 608 patients were included, including 415 patients with Fazekas score of 0 and 193 patients with Fazekas score of 3: 6. The results of multivariate Logistic regression showed that there was a significant positive correlation between the aged (G3 vs G1: OR10.81m95 CI 2.7642.38P0.001G4 vs G1:OR 28.4095CI 7.02114.95.P0.05G5 vs G1:OR 68.79-95CI 14.22332.92P0.05), cerebral atherosclerosis (OR 1.9895CI 1.073.65P0.029) and hypertension (OR4.895CI2.658.85) and severe leukoaraiosis (P 0.05). Conclusion Age, atherosclerosis and hypertension may be independent risk factors for severe leukoaraiosis.
【作者單位】： 武漢大學(xué)中南醫(yī)院神經(jīng)內(nèi)科;
【基金】：國(guó)家自然科學(xué)基金面上項(xiàng)目(81371273)
【分類(lèi)號(hào)】：R742

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