【摘要】：目的:探討肝性腦病(HE)不同嚴(yán)重程度患者大腦靜息態(tài)低頻振蕩幅度以及腦代謝的差異,為患者的治療提供依據(jù)。方法:選取本院2014年5月-2016年5月的32例HE患者進(jìn)行研究,依據(jù)其病情的嚴(yán)重程度分為兩組,輕度肝性腦病(MHE)組22例,重度肝性腦病(OHE)組10例。選取同期進(jìn)行身體檢查的健康受試者13例作為對(duì)照組,分別使用BOLD-fMRI、磁共振波譜檢查三組患者的靜息狀態(tài)下腦功能情況,分析腦代謝物的異常情況。結(jié)果:與對(duì)照組相比,MHE與OHE組患者的腦部默認(rèn)網(wǎng)絡(luò)區(qū)和小腦區(qū)內(nèi)的分?jǐn)?shù)化低頻振蕩幅度值顯著降低,顳中回內(nèi)、額中回和腦室旁白質(zhì)區(qū)的分?jǐn)?shù)化低頻振蕩幅度則顯著升高。MHE組患者腦代謝物Cho/Cr(0.93±0.11,0.80±0.16)與mI/Cr(0.26±0.08,0.20±0.06)顯著大于OHE組(P0.05),MHE組和OHE組NAA/Cr分別為1.93±0.15、2.03±0.22,差異無(wú)統(tǒng)計(jì)學(xué)意義(P=0.51)。HE患者代謝物峰值下面積比值均顯著低于正常對(duì)照組(NAA/Cr 2.78±0.19,Cho/Cr 1.20±0.13,mI/Cr 0.43±0.05,P0.05)。結(jié)論:HE越嚴(yán)重其靜息態(tài)默認(rèn)網(wǎng)絡(luò)區(qū)和小腦區(qū)內(nèi)的低頻振蕩幅度降低,顳中回內(nèi)、額中回和腦室旁白質(zhì)區(qū)低頻震蕩幅度則明顯升高。HE患者腦代謝物峰下面積比值越低提示病情越嚴(yán)重,為其診斷和治療提供參考。
[Abstract]:Objective: to investigate the amplitude of low frequency oscillations and brain metabolism in patients with hepatic encephalopathy (HE) with different severity. Methods: a total of 32 patients with HE were selected from May 2014 to May 2016. According to the severity of the disease, they were divided into two groups: 22 patients with mild hepatic encephalopathy (MHE) and 10 patients with severe hepatic encephalopathy (OHE). Thirteen healthy subjects who underwent physical examination at the same time were selected as the control group. The brain function in resting state was examined by using BOLD-fMRI and magnetic resonance spectroscopy respectively, and the abnormal state of brain metabolites was analyzed. Results: compared with the control group, the fractional low frequency oscillation amplitude in the default network area and cerebellar area of the patients in the MHE and OHE groups was significantly lower than that in the control group, and in the middle temporal gyrus. The fractional low frequency oscillation amplitude of middle frontal gyrus and paraventricular leukoplasm was significantly increased. The Cho/Cr and mI/Cr of MHE group were significantly higher than those of OHE group (P 0.05) and OHE group (1.93 鹵0.152.03 鹵0.22, respectively). There was no significant difference between MHE group and OHE group (P < 0.51). The product ratio was significantly lower than that in the normal control group (NAA/Cr 2.78 鹵0.19) (P 0.05). Conclusion the lower amplitude of low-frequency oscillation in rest default network area and cerebellar area is, the more serious the structure of the middle temporal gyrus is, the more serious it is, the lower the amplitude of oscillation is. The lower the ratio of subpeak area of brain metabolites in patients with HE, the more serious the disease is, which provides a reference for diagnosis and treatment.
【作者單位】： 甘肅省蘭州市第二人民醫(yī)院醫(yī)學(xué)影像科;
【基金】：蘭州市人才創(chuàng)新創(chuàng)業(yè)科技計(jì)劃項(xiàng)目(2015-RC-56)
【分類號(hào)】：R445.2;R747.9

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 郭銘菊;;肝性腦病早期患者的臨床觀察及護(hù)理[J];中國(guó)中醫(yī)藥現(xiàn)代遠(yuǎn)程教育;2008年09期

2 薛娟;;肝性腦病的觀察與護(hù)理[J];工企醫(yī)刊;2009年02期

3 何艷;;肝性腦病的預(yù)防和護(hù)理[J];國(guó)際醫(yī)藥衛(wèi)生導(dǎo)報(bào);2009年20期

4 張麗華;包曉春;姚琳;朱敏;;肝性腦病患者的臨床觀察及護(hù)理體會(huì)[J];現(xiàn)代中西醫(yī)結(jié)合雜志;2011年15期

5 王效軍;;改善護(hù)理·預(yù)防肝性腦病[J];國(guó)外醫(yī)學(xué).護(hù)理學(xué)分冊(cè);1991年04期

6 黃順坤;46例肝性腦病的觀察及護(hù)理[J];廣東醫(yī)學(xué)院學(xué)報(bào);2000年03期

7 趙立民;肝性腦病的現(xiàn)代護(hù)理[J];華夏醫(yī)學(xué);2000年05期

8 柳秀芝,賀亮,馬鳳艷;41例肝性腦病早期患者的臨床觀察及護(hù)理[J];黑龍江醫(yī)學(xué);2000年10期

9 凌柳青,李永蓮;18例肝性腦病的護(hù)理體會(huì)[J];蛇志;2000年02期

10 亓淑玲,潘峰,劉希芬;早期識(shí)別肝性腦病的護(hù)理體會(huì)[J];齊魯護(hù)理雜志;2001年09期

相關(guān)會(huì)議論文 前10條

1 劉寶華;;肝性腦病患者的預(yù)見性觀察與護(hù)理[A];中華中醫(yī)藥學(xué)會(huì)脾胃病分會(huì)第十九次全國(guó)脾胃病學(xué)術(shù)交流會(huì)論文匯編[C];2007年

2 柴國(guó)勇;陳先君;;肝性腦病的早期行為特征觀察及護(hù)理[A];浙江省第十九屆農(nóng)村衛(wèi)生改革與發(fā)展學(xué)術(shù)會(huì)議大會(huì)論文集[C];2011年

3 張振香;李俊玲;丁順英;;肝性腦病早期患者39例臨床觀察及護(hù)理[A];河南省護(hù)理學(xué)會(huì)內(nèi)科護(hù)理專業(yè)新知識(shí)、新進(jìn)展、健康老齡化護(hù)理學(xué)術(shù)交流會(huì)議論文匯編[C];2005年

4 羅娟;;30例肝性腦病患者臨床觀察及護(hù)理體會(huì)[A];2013年貴州省醫(yī)學(xué)會(huì)消化及內(nèi)鏡學(xué)術(shù)年會(huì)暨貴州省中西醫(yī)結(jié)合消化學(xué)術(shù)年會(huì)論文匯編[C];2013年

5 李因茵;鮑鶴攻;李艷;賈雪紅;;肝性腦病的護(hù)理進(jìn)展[A];全國(guó)內(nèi)科護(hù)理學(xué)術(shù)交流暨專題講座會(huì)議論文匯編[C];2004年

6 楊坤;;肝性腦病病人的護(hù)理[A];中國(guó)中西醫(yī)結(jié)合學(xué)會(huì)第十八次全國(guó)消化系統(tǒng)疾病學(xué)術(shù)會(huì)議暨2006年全國(guó)中西醫(yī)結(jié)合消化系統(tǒng)疾病進(jìn)展學(xué)習(xí)班論文匯編[C];2006年

7 沈清慧;;肝性腦病的護(hù)理觀察[A];全國(guó)傳染病護(hù)理學(xué)術(shù)交流暨專題講座會(huì)議論文匯編[C];2006年

8 張春蘭;于金春;張芳;;肝性腦病患者的護(hù)理措施及體會(huì)[A];甘肅省中醫(yī)藥學(xué)會(huì)2012年學(xué)術(shù)年會(huì)論文匯編[C];2012年

9 王春輝;;肝性腦病的觀察與護(hù)理[A];全國(guó)傳染病護(hù)理學(xué)術(shù)交流暨專題講座會(huì)議論文匯編[C];2004年

10 高迪;劉麗敏;曹Z，

本文編號(hào)：2176974