累積血壓暴露值對腦卒中事件的預(yù)測價值
發(fā)布時間：2018-08-02 16:19
【摘要】：目的探討累積血壓暴露[累積收縮壓(cumSBP)和累積舒張壓(cumDBP)]對腦卒中的預(yù)測價值。方法采取前瞻性隊列研究方法,以參加2006-2007、2008-2009、2010-2011年開灤集團(tuán)健康體檢的無腦卒中病史的職工53 582人為觀察對象,以腦卒中發(fā)生為終點事件。依據(jù)cumSBP(mm Hg·年)和cumDBP(mm Hg·年)四分位分組:cumSBP第1四分位組(480)、cumSBP第2四分位組(480~520)、cumSBP第3四分位組(520~560)、cumSBP第4四分位組(≥560),cumDBP第1四分位組(320)、cumDBP第2四分位組(320~340)、cumDBP第3四分位組(340~360)、cumDBP第4四分位組(≥360)。用壽命表法計算總?cè)巳翰煌琧umSBP、cumDBP的累積腦卒中發(fā)生率,并采用Cox比例風(fēng)險模型分析cumSBP、cumDBP第4四分位組對腦卒中事件的影響。結(jié)果觀察對象53 582人中,男性41 171人(76.8%),女性12 411人(23.2%),年齡(49.0±11.8)歲。隨訪(2.99±0.40)年,共發(fā)生腦卒中事件526例。總?cè)巳耗X卒中事件累積發(fā)生率隨著cumSBP、cumDBP的增高而呈上升趨勢。多因素Cox比例風(fēng)險回歸模型分析顯示,與cumSBP第1四分位組相比,cumSBP第3、4四分位組發(fā)生腦卒中事件的HR值(95%CI)分別為1.69(1.21~2.35)、2.03(1.47~2.80);與cumDBP第1四分位組相比,cumDBP第3、4四分位組發(fā)生腦卒中事件的HR值(95%CI)分別為1.46(1.07~1.98)、1.86(1.41~2.46)。結(jié)論高cumSBP和高cumDBP是發(fā)生腦卒中事件的危險因素。
[Abstract]:Objective to investigate the predictive value of cumulative blood pressure exposure [cumulative systolic pressure (cumSBP) and cumulative diastolic pressure (cumDBP)] for cerebral apoplexy. Methods a prospective cohort study was adopted to observe the incidence of stroke in 53582 workers who participated in the medical history of Kailuan Kailuan Group for 2006-20072008-20092010-2011 in the history of apoplexy without stroke. According to cumSBP (mm Hg year) and cumDBP (mm Hg year) four sub division groups: cumSBP first four partition group (480), cumSBP second four partition group (480~520), cumSBP third four bit group (520~560), cumSBP fourth four sub group (560), first four bits group (320) Group (> 360). Use the life table method to calculate the cumulative stroke incidence of cumSBP and cumDBP in the total population, and to analyze the impact of cumSBP and cumDBP fourth four on stroke events by the Cox proportional hazard model. Results among 53582 men, 41171 men (76.8%), 12411 women (23.2%), and age (49 + 11.8) years of age were followed up (2.99 + 0.40). There were 526 cases of stroke events in the year. The cumulative incidence of stroke events in the total population increased with the increase of cumSBP and cumDBP. The multiple factor Cox proportional risk regression model showed that the HR value of stroke events in cumSBP 3,4 four group was 1.69 (1.21~2.35) and 2.03 (1.47~2.), 2.03 (1.47~2.), respectively, and 2.03 (1.47~2.). 80); compared with the cumDBP first four group, the HR value of stroke events in the cumDBP 3,4 four division (95%CI) was 1.46 (1.07~1.98) and 1.86 (1.41~2.46). Conclusion high cumSBP and high cumDBP were the risk factors for the occurrence of stroke events.
【作者單位】： 開灤總醫(yī)院心內(nèi)科;華北理工大學(xué)研究生院;華北理工大學(xué)附屬醫(yī)院;
【分類號】：R743.3
本文編號：2159994
[Abstract]:Objective to investigate the predictive value of cumulative blood pressure exposure [cumulative systolic pressure (cumSBP) and cumulative diastolic pressure (cumDBP)] for cerebral apoplexy. Methods a prospective cohort study was adopted to observe the incidence of stroke in 53582 workers who participated in the medical history of Kailuan Kailuan Group for 2006-20072008-20092010-2011 in the history of apoplexy without stroke. According to cumSBP (mm Hg year) and cumDBP (mm Hg year) four sub division groups: cumSBP first four partition group (480), cumSBP second four partition group (480~520), cumSBP third four bit group (520~560), cumSBP fourth four sub group (560), first four bits group (320) Group (> 360). Use the life table method to calculate the cumulative stroke incidence of cumSBP and cumDBP in the total population, and to analyze the impact of cumSBP and cumDBP fourth four on stroke events by the Cox proportional hazard model. Results among 53582 men, 41171 men (76.8%), 12411 women (23.2%), and age (49 + 11.8) years of age were followed up (2.99 + 0.40). There were 526 cases of stroke events in the year. The cumulative incidence of stroke events in the total population increased with the increase of cumSBP and cumDBP. The multiple factor Cox proportional risk regression model showed that the HR value of stroke events in cumSBP 3,4 four group was 1.69 (1.21~2.35) and 2.03 (1.47~2.), 2.03 (1.47~2.), respectively, and 2.03 (1.47~2.). 80); compared with the cumDBP first four group, the HR value of stroke events in the cumDBP 3,4 four division (95%CI) was 1.46 (1.07~1.98) and 1.86 (1.41~2.46). Conclusion high cumSBP and high cumDBP were the risk factors for the occurrence of stroke events.
【作者單位】： 開灤總醫(yī)院心內(nèi)科;華北理工大學(xué)研究生院;華北理工大學(xué)附屬醫(yī)院;
【分類號】：R743.3
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