發(fā)布時(shí)間：2018-08-01 13:28

【摘要】：目的探討75歲以上原發(fā)性帕金森病患者行丘腦底核(subthalamic nucleus,STN)腦深部電刺激術(shù)(deep brain stimulation,DBS)的臨床療效。方法收集我科行STN-DBS治療的24例原發(fā)性帕金森病患者,分為A、B兩組進(jìn)行對(duì)比研究。A組(75歲)16例,B組(≥75歲)8例。對(duì)兩組患者療效及并發(fā)癥進(jìn)行對(duì)比分析(平均隨訪7.5個(gè)月)。結(jié)果患者術(shù)后帕金森氏病綜合評(píng)分量表(unified Parkinson's disease rating scale,UPDRS)評(píng)分改善比較,其中UPDRSⅢ75歲以上患者與75歲以下患者兩組比較無(wú)差異(Z=-0.429,P=0.668),UPDRSⅡ及ADL評(píng)分改善百分比兩組統(tǒng)計(jì)也無(wú)差異(Z=-0.551,P=0.581)。帕金森病39問(wèn)卷表(Parkinson’s disease questionnaire-39,PDQ-39)評(píng)分改善兩組無(wú)差異(Z=-0.245,P=0.806)。美多芭劑減少量?jī)山M比較無(wú)差異(Z=-0.282,P=0.778)。24例患者并發(fā)癥(術(shù)后90 d內(nèi)):術(shù)后嗜睡和譫妄,A組3例,B組2例;精神癥狀,A組1例,B組2例;術(shù)后肺部感染,A組1例,B組1例;右側(cè)鎖骨下皮下積液,B組1例;幻覺(jué),B組1例;手術(shù)切口延遲愈合,A組1例,B組1例。遠(yuǎn)期并發(fā)癥:構(gòu)音障礙,體重增加發(fā)生率無(wú)明顯差別。結(jié)論表明75歲以上帕金森病患者STN-DBS手術(shù)同樣取得療效,并發(fā)癥發(fā)生率有所增加。
[Abstract]:Objective to investigate the clinical effect of (deep brain stimulation in patients with primary Parkinson's disease (PD) over 75 years of age. Methods Twenty-four patients with primary Parkinson's disease treated with STN-DBS were divided into two groups: group A (aged 75), group B (n = 16) and group B (鈮，

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