【摘要】：一氧化碳中毒后的急性腦損傷和遲發(fā)型腦病嚴(yán)重影響患者的預(yù)后及生存質(zhì)量。高壓氧作為臨床治療一氧化碳中毒性腦損傷的主要方法爭(zhēng)議頗多,而一氧化碳中毒性腦損傷的發(fā)病機(jī)制目前也尚未明確。核因子紅細(xì)胞2相關(guān)因子2(Nrf-2)的激活可能對(duì)一氧化碳中毒引發(fā)的炎癥、凋亡等發(fā)揮較好的治療作用。因此,研究Nrf-2在一氧化碳中毒性腦損傷發(fā)病機(jī)制中的作用可為一氧化碳中毒后急性腦損傷和遲發(fā)型腦病的靶向治療提供新思路。
[Abstract]:Acute brain injury and delayed encephalopathy after carbon monoxide poisoning seriously affect the prognosis and quality of life. Hyperbaric oxygen (HBO) is the main method for the treatment of carbon monoxide poisoning brain injury, and the pathogenesis of carbon monoxide poisoning brain injury is not clear. Activation of nuclear factor erythrocyte 2 related factor 2 (Nrf-2) may play a better role in the treatment of inflammation and apoptosis induced by carbon monoxide poisoning. Therefore, the study of the role of Nrf-2 in the pathogenesis of carbon monoxide poisoning may provide a new approach for the targeted treatment of acute brain injury and delayed encephalopathy after carbon monoxide poisoning.
【作者單位】： 青島大學(xué)附屬煙臺(tái)毓璜頂醫(yī)院中西醫(yī)結(jié)合科;
【基金】：國(guó)家自然科學(xué)基金(81571283) 山東省醫(yī)藥衛(wèi)生科技發(fā)展計(jì)劃項(xiàng)目(2014WS0248)
【分類號(hào)】：R595.1;R747.9
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本文編號(hào)：2155619